Document Detail


Mitral valve compensation for annular dilatation: in vitro study into the mechanisms of functional mitral regurgitation with an adjustable annulus model.
MedLine Citation:
PMID:  10399664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM OF THE STUDY: Mitral annulus dilatation has been identified as an important factor in functional mitral regurgitation (FMR). However, the pathophysiologic interaction of annular dilatation and papillary muscle (PM) displacement in FMR, which occurs clinically in left ventricular (LV) dilatation, is still not well understood. It is difficult to separate these competing factors in vivo, leading to confusion in identifying the real role of the annular dilatation in FMR and its interaction with PM displacement. METHODS: To better understand the competing factors, an in vitro model was developed with a D-shaped adjustable mitral annulus that could be changed from 5.5 cm2 to 13.0 cm2 during experiments, independent of varying PM positions. Six excised normal porcine mitral valves were mounted in a left ventricular model with the adjustable annulus device and tested in a physiologic pulsatile flow system under normal cardiac output and left ventricular pressure (5.0 l/min, 120 mmHg). Papillary muscles were placed in normal and then displaced to an apical posterolateral position, to simulate pathological conditions seen clinically. Regurgitation was measured directly by a flow probe and the mitral valve geometry and leaflet coaptation were recorded by video camera through the model's atrium window. In addition, 2D echocardiography was used to evaluate leaflet coaptation and color Doppler flow mapping to detect the regurgitant flow field. RESULTS: The results showed that in normal PM position, the mitral regurgitant was consistently at low level until the annulus was enlarged to 1.75 times the normal size, at which time it increased sharply. Papillary muscle apical posterolateral displacement, which simulates a dilated LV, caused regurgitation to occur earlier (1.5 times the normal annulus size), and had an increased regurgitant volume (p < 0.05). The leaflet gaps were first observed at the commissural areas of the valves, consistent with the location of regurgitant jets detected by color Doppler flow mapping. Asymmetric PM displacement created more regurgitation than both the symmetric PM tethering (p = 0.063) and normal PM position (p < 0.01). The regurgitant jets were observed at the same commissural side as the PM displacement, even without significant enlargement of the annulus. CONCLUSIONS: This in vitro study provides insight into the interaction between annular dilatation and PM displacement on FMR. The resulting effects and their overall similarity to clinical observation could help further understand the mechanism of FMR and provide additional information to improve future therapeutic strategies.
Authors:
S He; J D Lemmon; M W Weston; M O Jensen; R A Levine; A P Yoganathan
Related Documents :
2395744 - Mitral regurgitation with gross deformity of a mitral leaflet due to kawasaki disease.
8910154 - Biplane transesophageal color-flow doppler imaging in assessing severity of mitral regu...
1856424 - Intraoperative transesophageal echocardiography of atrioventricular septal defect.
3958334 - Diastolic mitral regurgitation in patients with atrioventricular conduction abnormaliti...
2384604 - Evidence for altered epicardial coronary artery autoregulation as a cause of distal cor...
24088614 - Autoantibody prevalence with an improved immunoassay for detecting cardiac troponin-spe...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  8     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-17     Completed Date:  1999-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  294-302     Citation Subset:  IM    
Affiliation:
School of Biomedical Engineering, Georgia Institute of Technology, Atlanta 30332-0535, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Dilatation, Pathologic
Hemodynamics
Humans
Mitral Valve / physiopathology*
Mitral Valve Insufficiency / pathology,  physiopathology*
Models, Cardiovascular*
Papillary Muscles / pathology
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intraoperative transesophageal echocardiography for evaluation of mitral valve repair.
Next Document:  Collapse and massive pulmonary edema secondary to thrombosis of a mitral mechanical heart valve pros...