| Mitral and tricuspid annular velocities determined by Doppler tissue imaging in hypopituitary, growth hormone-deficient patients. | |
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MedLine Citation:
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PMID: 16166781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study is to determine systolic and diastolic velocity profiles of the left and right ventricles by tissue Doppler imaging (TDI) and to reveal the associations between TDI parameters and early atherosclerotic changes in adult hypopituitary patients with GH deficiency. PATIENTS AND METHODS: The study group is composed of 16 hypopituitary, GH-deficient patients and 13 healthy controls. All patients had been receiving adequate substitution therapy other than GH at stable doses for at least 6 months. Conventional Doppler echocardiography and TDI of the mitral and tricuspid annulus were performed. Intima-media thickness (IMT) of the common carotid artery was calculated. RESULTS: IMT was significantly higher in the hypopituitary group compared with controls (0.83 +/- 0.25 vs. 0.51 +/- 0.14 mm, p < 0.001). Hypopituitary patients had significantly lower peak early diastolic (Em) mitral annular velocity (11.2 +/- 3.0 vs. 13.9 +/- 2.8 cm/s, p < 0.05). Multiple regression analysis revealed that age was the only independent variable significantly associated with Em and IMT in the patients. CONCLUSION: Diastolic abnormalities on TDI of the mitral annulus and early atherosclerotic changes occur concurrently in asymptomatic hypopituitary patients with GH deficiency. Aging may have a more deleterious effect on ventricular function and atherogenesis in this group of patients. |
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Authors:
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Alper Yurci; Huseyin Oflaz; Mehmet Meric; Nese Ozbey |
Publication Detail:
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Type: Journal Article Date: 2005-09-15 |
Journal Detail:
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Title: Hormone research Volume: 64 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-10-24 Completed Date: 2005-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 107-14 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 S. Karger AG, Basel. |
Affiliation:
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Department of Medicine, Department of Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aging Atherosclerosis / pathology Blood Flow Velocity Diastole Echocardiography, Doppler Female Human Growth Hormone / deficiency* Humans Hypopituitarism / drug therapy, physiopathology* Male Middle Aged Mitral Valve / physiopathology*, ultrasonography Regression Analysis Systole Tricuspid Valve / physiopathology*, ultrasonography Ventricular Function, Left Ventricular Function, Right |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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