Document Detail

Mitral regurgitation determined by radionuclide cardiography: dependence on posture and exercise.
MedLine Citation:
PMID:  7917689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate dependence of posture and exercise on the degree of mitral regurgitation using combined first pass and equilibrium radionuclide cardiography. DESIGN: 24 patients with clinically stable chronic mitral regurgitation and sinus rhythm were studied by first pass list mode and simultaneous multigated frame mode equilibrium radionuclide cardiography using red cells labelled with technetium-99m. RESULTS: When patients changed posture from supine to sitting upright, left ventricular volumes decreased considerably. Regurgitation tended to increase in patients with valve prolapse but decreased in patients with ischaemic heart disease and dilated cardiomyopathy. During submaximal bicycle exercise cardiac output increased without dilatation of the left ventricle. The increase in left ventricular forward stroke volume was more pronounced than that in the total stroke volume, leading to a considerable decrease in the regurgitant flow through the mitral valve. The repeatability and observer variability of radionuclide determination of regurgitation was acceptable, with limits of agreement within about 10%. CONCLUSIONS: Change in posture induces a normal haemodynamic response in most patients with chronic mitral regurgitation; the effect of posture on regurgitation depends on the underlying disease. Mild to moderate exercise causes no deterioration in the severity of regurgitation.
H Kelbaek; J Aldershvile; K Skagen; P Hildebrandt; S L Nielsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  72     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-11-01     Completed Date:  1994-11-01     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  AIM; IM    
Department of Medicine B, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Aged, 80 and over
Blood Pressure / physiology
Exercise / physiology*
Heart / physiopathology,  radionuclide imaging*
Heart Rate / physiology
Middle Aged
Mitral Valve Insufficiency / physiopathology,  radionuclide imaging*,  surgery
Observer Variation
Reproducibility of Results
Stroke Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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