| Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. | |
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MedLine Citation:
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PMID: 22320434 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman. Four years before, she underwent a mitral valve replacement after the diagnosis of mitral regurgitation during benfluorex treatment (150 mg/day). This drug was reintroduced postoperatively. She presented with exercise and sometimes resting dyspnoea. The bioprosthesis and aortic valves exhibited similar histopathological lesions. Thickening and plaque deposits made by smooth muscle alpha actin- and vimentin-positive cells in a glycosaminoglycan matrix were observed. The study discusses the putative contribution of circulating progenitor cells activated by 5-HT(2B) receptor agonists in the development of drug-induced heart disease. |
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Authors:
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Estelle Ayme-Dietrich; Roland Lawson; Bernard Gasser; Robert Dallemand; Nicolas Bischoff; Laurent Monassier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: - ISSN: 1472-8206 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Fundamental and Clinical Pharmacology © 2012 Société Française de Pharmacologie et de Thérapeutique. |
Affiliation:
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Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Faculté de Médecine, Université de Strasbourg, 11 rue Humann, 67085 Strasbourg & CHU de Strasbourg, 1 place de l'Hôpital, 67091 Strasbourg, France Centre Hospitalier de Mulhouse, 20 avenue du Docteur René Laennec, 68100 Mulhouse, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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