| Mitral annulus size links ventricular dilatation to functional mitral regurgitation. | |
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MedLine Citation:
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PMID: 16153522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the impact of annulus size and valve deformation (tethering) on mitral regurgitation in the animal dilated cardiomyopathy model, and assessed if acute left ventricular volume changes affect mitral annulus dimensions. We performed 3-dimensional echocardiography in 30 open-chest dogs with pacing-induced cardiomyopathy. Mitral annulus area was calculated from its two orthogonal diameters, whereas valve tethering was quantified by valve tenting area measurement. Mitral valve regurgitant volume showed the highest correlation with annulus area (r = 0.64, P < .001), left atrial volume (r = 0.40, P < .01), and left ventricular end-diastolic volume (r = 0.37, P < .01). Regurgitant volume showed poorer correlation with valve tethering in both septolateral and intercommissural planes (r = 0.35 and r = 0.31, P < .05 for both). Annulus dimensions correlated with acute changes of left ventricular end-diastolic volume (r = 0.68, P = .002). Mitral annulus dilation is the strongest predictor of functional mitral regurgitation in this animal dilated cardiomyopathy model. |
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Authors:
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Zoran B Popović; Maureen Martin; Kiyotaka Fukamachi; Masahiro Inoue; Jun Kwan; Kazuyoshi Doi; Jian Xin Qin; Takahiro Shiota; Mario J Garcia; Patrick M McCarthy; James D Thomas |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 18 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2006-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 959-63 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathy, Dilated / etiology, ultrasonography* Dogs Echocardiography / methods Mitral Valve / ultrasonography* Mitral Valve Insufficiency / etiology, ultrasonography* Mitral Valve Stenosis / etiology, ultrasonography* Reproducibility of Results Sensitivity and Specificity Statistics as Topic Ventricular Dysfunction, Left / etiology, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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