Document Detail

Mitral annulus size links ventricular dilatation to functional mitral regurgitation.
MedLine Citation:
PMID:  16153522     Owner:  NLM     Status:  MEDLINE    
We compared the impact of annulus size and valve deformation (tethering) on mitral regurgitation in the animal dilated cardiomyopathy model, and assessed if acute left ventricular volume changes affect mitral annulus dimensions. We performed 3-dimensional echocardiography in 30 open-chest dogs with pacing-induced cardiomyopathy. Mitral annulus area was calculated from its two orthogonal diameters, whereas valve tethering was quantified by valve tenting area measurement. Mitral valve regurgitant volume showed the highest correlation with annulus area (r = 0.64, P < .001), left atrial volume (r = 0.40, P < .01), and left ventricular end-diastolic volume (r = 0.37, P < .01). Regurgitant volume showed poorer correlation with valve tethering in both septolateral and intercommissural planes (r = 0.35 and r = 0.31, P < .05 for both). Annulus dimensions correlated with acute changes of left ventricular end-diastolic volume (r = 0.68, P = .002). Mitral annulus dilation is the strongest predictor of functional mitral regurgitation in this animal dilated cardiomyopathy model.
Zoran B Popović; Maureen Martin; Kiyotaka Fukamachi; Masahiro Inoue; Jun Kwan; Kazuyoshi Doi; Jian Xin Qin; Takahiro Shiota; Mario J Garcia; Patrick M McCarthy; James D Thomas
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  18     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  959-63     Citation Subset:  IM    
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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MeSH Terms
Cardiomyopathy, Dilated / etiology,  ultrasonography*
Echocardiography / methods
Mitral Valve / ultrasonography*
Mitral Valve Insufficiency / etiology,  ultrasonography*
Mitral Valve Stenosis / etiology,  ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Ventricular Dysfunction, Left / etiology,  ultrasonography*

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