| Mitral annular remodeling to treat functional mitral regurgitation: a pilot acute study in a canine model. | |
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MedLine Citation:
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PMID: 20719728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). METHODS: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. RESULTS: The injection improved MR grade from 3.4 +/- 0.8 to 1.3 +/- 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 +/- 0.4 cm to 2.9 +/- 0.3 cm; P = .039) and MR volume (20.6 +/- 7.3 mm3 to 5.2 +/- 2.2 mm3; P = .044). CONCLUSIONS: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model. |
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Authors:
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Hideyuki Fumoto; Tohru Takaseya; Akira Shiose; Roberto M Saraiva; Yoko Arakawa; Margaret Park; Santosh Rao; Raymond Dessoffy; Ji-Feng Chen; Qun Zhou; Anthony Calabro; Michael Banbury; Kiyotaka Fukamachi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The heart surgery forum Volume: 13 ISSN: 1522-6662 ISO Abbreviation: Heart Surg Forum Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891112 Medline TA: Heart Surg Forum Country: United States |
Other Details:
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Languages: eng Pagination: E247-50 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Echocardiography Feasibility Studies Heart Ventricles Hyaluronic Acid / administration & dosage* Hydrogel / administration & dosage* Injections, Intramuscular Mitral Valve Insufficiency / physiopathology*, therapy*, ultrasonography Papillary Muscles Pilot Projects Postoperative Period Severity of Illness Index Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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1 R21HL081567-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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25852-47-5/Hydrogel; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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