Document Detail

Mitral annular remodeling to treat functional mitral regurgitation: a pilot acute study in a canine model.
MedLine Citation:
PMID:  20719728     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR).
METHODS: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection.
RESULTS: The injection improved MR grade from 3.4 +/- 0.8 to 1.3 +/- 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 +/- 0.4 cm to 2.9 +/- 0.3 cm; P = .039) and MR volume (20.6 +/- 7.3 mm3 to 5.2 +/- 2.2 mm3; P = .044).
CONCLUSIONS: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.
Hideyuki Fumoto; Tohru Takaseya; Akira Shiose; Roberto M Saraiva; Yoko Arakawa; Margaret Park; Santosh Rao; Raymond Dessoffy; Ji-Feng Chen; Qun Zhou; Anthony Calabro; Michael Banbury; Kiyotaka Fukamachi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The heart surgery forum     Volume:  13     ISSN:  1522-6662     ISO Abbreviation:  Heart Surg Forum     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891112     Medline TA:  Heart Surg Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E247-50     Citation Subset:  IM    
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
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MeSH Terms
Feasibility Studies
Heart Ventricles
Hyaluronic Acid / administration & dosage*
Hydrogel / administration & dosage*
Injections, Intramuscular
Mitral Valve Insufficiency / physiopathology*,  therapy*,  ultrasonography
Papillary Muscles
Pilot Projects
Postoperative Period
Severity of Illness Index
Treatment Outcome
Grant Support
1 R21HL081567-01/HL/NHLBI NIH HHS
Reg. No./Substance:
25852-47-5/Hydrogel; 9004-61-9/Hyaluronic Acid

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