| Mitral annular reduction with subablative therapeutic ultrasound: pre-clinical evaluation of the ReCor device. | |
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MedLine Citation:
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PMID: 20542798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate the potential for mitral annular (MA) size reduction using a novel device utilising therapeutic ultrasound (TU). METHODS AND RESULTS: The ReCor device (ReCor Medical, Inc., Ronkonkoma, NY, USA, Investigational device, not for use in human application) was studied in a closed chest canine animal model (35 dogs). Under fluoroscopy, a 12 Fr TU balloon catheter was advanced into the left atrium (transseptal approach). The TU balloon was inflated with contrast-saline, positioned at the MA and energy delivered circumferentially, to heat the tissue locally. Five TU applications were delivered (at least 60W for at least 40 sec). Relative to baseline, mitral valve annular diameter reduction (measured by transthoracic echocardiography) was 8.4% immediately post procedure(p<0.001), 8.6% at one week (p<0.001), 8.8% at two weeks (p<0.001), 9.3% at three weeks (p<0.001), 10.8% at four weeks (p<0.001), 8.6% at three months (p<0.001) and 5.7% at six months (p<0.001). Histology showed an increase in elastin associated with tissue thickening at the annular level. Transmission electron microscopy demonstrated a decrease in diameter of individual collagen fibres in treated regions compared to controls. CONCLUSIONS: Therapeutic ultrasound (TU) energy application to the mitral annulus is feasible percutaneously. A reduction in annular dimensions occurs immediately and appears to be durable without peri-annular damage. |
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Authors:
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Hasan Jilaihawi; Renu Virmani; Hiroshi Nakagawa; Anique Ducharme; Yan-Fen Shi; Naima Carter-Monroe; Elena Ladich; Mano Iyer; Atsushi Ikeda; Anita Asgar; Raoul Bonan |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology Volume: 6 ISSN: 1969-6213 ISO Abbreviation: EuroIntervention Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251040 Medline TA: EuroIntervention Country: France |
Other Details:
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Languages: eng Pagination: 54-62 Citation Subset: IM |
Affiliation:
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Interventional Cardiology, Montréal Heart Institute, Montreal, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheter Ablation / instrumentation* Dogs Echocardiography, Doppler Elastin / metabolism Equipment Design Feasibility Studies Fibrillar Collagens / ultrastructure Materials Testing Microscopy, Electron, Transmission Mitral Valve / metabolism, surgery*, ultrasonography, ultrastructure Models, Animal Radiography, Interventional Time Factors Ultrasonic Therapy / instrumentation* |
| Chemical | |
Reg. No./Substance:
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0/Fibrillar Collagens; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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