Document Detail


Mitral annular calcium causing mitral stenosis.
MedLine Citation:
PMID:  20102954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitral annular calcium (MAC) is a common finding at echocardiography, although it is an unusual cause of severe mitral stenosis. Although MAC is known to be associated with atherosclerosis and chronic kidney disease, little is known about its natural history as affects mitral valve function. This report describes a cohort of 37 outpatients with severe MAC (>5 mm) of whom 32 were followed longitudinally with echocardiography (mean follow-up 2.6 + or - 1.6 years). Progression of the mitral valve gradient occurred in 16 of 32 (50%). There was wide variation in rate of progression with a few subjects demonstrating a rapid increase in gradient, up to 9 mm Hg/year. Progression of mitral valve gradient correlated with baseline gradient at rest and with severity of overall cardiac calcification as measured by a semiquantitative echocardiographic score. Age at index echocardiogram was inversely related to mitral valve gradient after baseline, suggesting that calcification may proceed at a greater rate in younger patients. In conclusion, although severe mitral stenosis is uncommon in patients with MAC, those with a pre-existing gradient at rest and severe overall cardiac calcification appear to be at greater risk for development of this disease state.
Authors:
Gregg S Pressman; Ashish Agarwal; Leonard E Braitman; Salman M Muddassir
Related Documents :
9129854 - Transseptal mitral balloon valvotomy in patients with atrial septal aneurysms.
8402764 - Structural basis for mitral valve dysfunction associated with ostium secundum atrial se...
10941544 - Increased platelet activation and endothelial dysfunction in patients with atrial fibri...
21998064 - Cardiac cycle-related volume change in unruptured cerebral aneurysms: a detailed volume...
12744354 - Guglielmi detachable coil embolization of cerebral aneurysms: 11 years' experience.
1699294 - External detection of pulmonary accumulation of indium-113m labelled transferrin in the...
Publication Detail:
Type:  Journal Article     Date:  2009-12-22
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-91     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Cardiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA. PressmanG@einstein.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Calcinosis / complications*,  pathology,  ultrasonography
Cohort Studies
Disease Progression
Echocardiography*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Mitral Valve / pathology,  ultrasonography
Mitral Valve Stenosis / etiology*,  pathology,  ultrasonography
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic effect of long-axis left ventricular dysfunction and B-type natriuretic peptide levels in...
Next Document:  Usefulness of delayed enhancement by magnetic resonance imaging in hypertrophic cardiomyopathy as a ...