Document Detail


Mitotically active juvenile xanthogranuloma.
MedLine Citation:
PMID:  12296763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Juvenile xanthogranuloma is a histiocytic inflammatory disorder capable of presenting different histologic patterns. The classic form consists of sheets of foamy histiocytes and numerous multinucleated Touton-type giant cells containing no to very few mitotic figures. Nonlipidized juvenile xanthogranuloma consists of a diffuse monomorphic histiocytic infiltrate and usually shows a slightly higher mitotic index. Histologic hematoxylin-eosin staining techniques were used after excision of a pink ulcerated nodule in a 2-year-old girl. Histopathologic examination showed a nonencapsulated cellular proliferation mainly occupying dermis, but extending into the subcutaneous tissue as well. Most of the cells were epithelioid histiocytes, but foamy and Touton giant cells were also evident. The most striking feature was the presence of a high number of mitotic figures, as many as 23 per 10 high-power fields. We present an unusual case of classic juvenile xanthogranuloma with areas similar to those found in the nonlipidized type and with a high mitotic index.
Authors:
Ana Miguélez; Jose Luis Rodríguez-Peralto; Angel Santos-Briz; Javier Vargas; Fernando López-Ríos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  126     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-25     Completed Date:  2002-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1219-21     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Female
Humans
Mitotic Index*
Shoulder
Treatment Outcome
Xanthogranuloma, Juvenile / pathology*,  surgery

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