Document Detail


Mitotic arrest and toxicity in Biomphalaria glabrata (Mollusca: Pulmonata) exposed to colchicine.
MedLine Citation:
PMID:  15950238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous exposure of Biomphalaria glabrata snails to 0.1% colchicine resulted in a significant increase, relative to non-exposed snails, in the number of arrested mitotic figures in the amebocyte-producing organ (APO) as soon as 4 h, with peak numbers after 12 h of exposure. The number of circulating hemocytes was significantly elevated at 24 h. However, by 72 h both the number of mitotic figures in the APO and the concentration of circulating hemocytes in the hemolymph had returned to control levels. Hemocytes appeared to possess normal morphology throughout this exposure, including the formation of long filopodia with supporting rodlike structures that have been reported to contain microtubules. Snail survival decreased as a function of exposure time. Significantly fewer snails, relative to controls, survived a 48-h exposure, and only 1 out of 30 snails recovered from a 72-h exposure to 0.1% colchicine. Colchicine-exposed snails displayed intoxicated behavior, even upon removal from the colchicine solution, although no histopathology was evident in the CNS of snails exposed for 72 h.
Authors:
John T Sullivan; Lina Castro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2005-06-13
Journal Detail:
Title:  Journal of invertebrate pathology     Volume:  90     ISSN:  0022-2011     ISO Abbreviation:  J. Invertebr. Pathol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2006-01-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0014067     Medline TA:  J Invertebr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Affiliation:
Department of Biology, University of San Francisco, 2130 Fulton Street, San Francisco, CA 94117, USA. sullivan@usfca.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomphalaria / cytology*
Cell Count
Colchicine / administration & dosage,  poisoning*
Dose-Response Relationship, Drug
Hemocytes / pathology
Hemolymph / cytology
Mitosis / drug effects*
Survival Analysis
Grant Support
ID/Acronym/Agency:
AI 50546/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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