| Mitotic activity of epidermal melanocytes in UV-irradiated mouse skin. | |
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MedLine Citation:
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PMID: 632619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of mitosis in the increase in the epidermal melanocyte population following repeated ultraviolet (UV) irradiation has been studied in C57B1 mice. Cumulative labeling with 3H-methyl-thymidine (3HTdr) was used in combination with autoradiography. A 4-6 fold increase in the melanocyte population was associated with an isotope labeling of 65-80% of the melanocytes. This indicates that cell division during the irradiation period can account for the total increase in the number of melanocytes. Labeled melanocytes were also found in the epidermis from unirradiated skin. Thus, the epidermal melanocytes seem to constitute a dynamic cell population under continuous renewal. |
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Authors:
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I K Rosdahl; G Szabó |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 70 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-05-17 Completed Date: 1978-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 143-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Cell Count Epidermis / cytology*, radiation effects Male Melanocytes / cytology*, radiation effects, ultrastructure Mice Mice, Inbred C57BL Mitosis / radiation effects* Thymidine / metabolism Ultraviolet Rays* |
| Chemical | |
Reg. No./Substance:
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50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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