| Mitomycin-induced hemolytic-uremic syndrome. | |
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MedLine Citation:
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PMID: 6210069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four patients who took the antitumor agent mitomycin manifested microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. At autopsy, kidneys from all four patients had a microangiopathy typical of the hemolytic-uremic syndrome (HUS), with thromboses in glomerular capillaries and arterioles, fibrin deposition in mesangium, and prominent cellular intimal proliferation of the interlobular arteries. Development of the HUS was an important factor contributing to death in all four patients. From a review of the literature and our initial results of a randomized chemotherapy protocol for metastatic adenocarcinoma of the colorectum, it appears that mitomycin was the most likely cause for the development of the HUS in these patients. As more patients are being treated with mitomycin, particular care must be taken to monitor them for development of a drug-induced HUS. |
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Authors:
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A D Proia; E A Harden; H R Silberman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 108 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1984-12-31 Completed Date: 1984-12-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 959-62 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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pathology Autopsy Capillaries / pathology Fibrin / analysis Glomerular Mesangium / analysis, pathology Hemolytic-Uremic Syndrome / chemically induced*, pathology Humans Kidney / pathology Kidney Glomerulus / blood supply, pathology Male Mitomycins / adverse effects* Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Mitomycins; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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