Document Detail

Mitomycin-induced hemolytic-uremic syndrome.
MedLine Citation:
PMID:  6210069     Owner:  NLM     Status:  MEDLINE    
Four patients who took the antitumor agent mitomycin manifested microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. At autopsy, kidneys from all four patients had a microangiopathy typical of the hemolytic-uremic syndrome (HUS), with thromboses in glomerular capillaries and arterioles, fibrin deposition in mesangium, and prominent cellular intimal proliferation of the interlobular arteries. Development of the HUS was an important factor contributing to death in all four patients. From a review of the literature and our initial results of a randomized chemotherapy protocol for metastatic adenocarcinoma of the colorectum, it appears that mitomycin was the most likely cause for the development of the HUS in these patients. As more patients are being treated with mitomycin, particular care must be taken to monitor them for development of a drug-induced HUS.
A D Proia; E A Harden; H R Silberman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  108     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1984-12-31     Completed Date:  1984-12-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  959-62     Citation Subset:  AIM; IM    
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MeSH Terms
Arteries / pathology
Capillaries / pathology
Fibrin / analysis
Glomerular Mesangium / analysis,  pathology
Hemolytic-Uremic Syndrome / chemically induced*,  pathology
Kidney / pathology
Kidney Glomerulus / blood supply,  pathology
Mitomycins / adverse effects*
Staining and Labeling
Reg. No./Substance:
0/Mitomycins; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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