| Mitomycin-C-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: cumulative toxicity of an old drug in a new era. | |
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MedLine Citation:
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PMID: 21859568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mitomycin-C (MMC) is a first-line therapy for anal squamous cell carcinoma (ASCC), and it continues to be used for several other indications. Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are serious complications of MMC therapy. Herein, we describe a 73-year-old woman with recurrent ASCC treated with MMC who developed chronic microangiopathic hemolytic anemia (MAHA) and thrombocytopenia after receiving a cumulative dose of 50 mg/m(2). These hematologic adverse events persisted for 9 months and resolved after discontinuation of chemotherapy followed by multiple courses of oral corticosteroids. This report describes an atypically chronic and mild form of secondary TTP/HUS and discusses the possible role of corticosteroids in its management. |
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Authors:
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Roland El-Ghazal; Nikolai Podoltsev; Peter Marks; Edward Chu; Muhammad Wasif Saif |
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Publication Detail:
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Type: Journal Article Date: 2011-04-22 |
Journal Detail:
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Title: Clinical colorectal cancer Volume: 10 ISSN: 1938-0674 ISO Abbreviation: Clin Colorectal Cancer Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-08-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120693 Medline TA: Clin Colorectal Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 142-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Hospital of St Raphael, New Haven, CT. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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