| Mitomycin C in the management of pediatric caustic esophageal strictures: a case report. | |
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MedLine Citation:
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PMID: 16677867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the incidence of caustic ingestion is declining, the management of caustic esophageal strictures remains a challenge. Mitomycin C (MMC) inhibits fibroblast proliferation and is effective in reducing scar in animal experiments. We report the case of a child with a distal esophageal stricture from lye ingestion managed with MMC. Despite repeated dilatations, at 1 year post injury, the stricture was 20% of esophageal diameter. Mitomycin C (4 microg/mL) was applied topically and circumferentially by endoscopy and repeated 4 months later. At 20 months follow-up, the child eats normally, and esophagram showed decreased stenosis (stricture was 50% of esophageal diameter). No complications were observed. Although controlled trials are required to confirm its efficacy, MMC should be considered as an adjunct in the management of caustic esophageal strictures in children. |
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Authors:
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Oluyinka O Olutoye; Robert J Shulman; Ronald T Cotton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 41 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-08 Completed Date: 2006-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: e1-3 Citation Subset: IM |
Affiliation:
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Pediatric Surgery Division, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030-2399, USA. oolutoye@bcm.tcm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Burns, Chemical
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complications*,
drug therapy* Esophageal Stenosis / chemically induced*, drug therapy* Humans Infant Male Mitomycin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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