Document Detail

Mitomycin C-activity effected by vitamins B1, C, E and beta-carotene under irradiation with gamma-rays.
MedLine Citation:
PMID:  12710736     Owner:  NLM     Status:  MEDLINE    
Vitamin B1 (thiamine) can essentially effect the activity of mitomycin C (MMC), added individually or in combination with antioxidant vitamins (C, E-acetate, beta-carotene) as found in experiments in vitro (Escherichia coli bacteria, AB 1157) under irradiation with gamma-rays. The environment plays a crucial role. In airfree media vitamin B1 leads to a 2-fold increase of the MMC-efficiency, but adding vitamin C it decreases. In the presence of all vitamins (B1, C, E-ac., and beta-carotene) the MMC-action increases about 1.8-fold. In aerated media vitamin B1 causes an about 4-times increase of the MMC-efficiency, but by adding vitamin B1 and C the MMC-activity decreases by a factor of two, whereas in the presence of B1, C, E-ac., and beta-carotene it rises again to 2.6-fold. In environment saturated with N2O (conversion of e(-)aq into OH radicals) a different picture is observed. The presence of vitamin B1 or vitamin B1 + C causes a strong decrease of the MMC-efficiency, but the addition of all vitamins (B1, C, E-ac., and beta-car.) leads to a small increase of the cytostatic action. The results demonstrate the influence of vitamin B1 used individually or in combination with other antioxidants on the MMC-efficiency and the strong effect of the environment. The results are of interest for the application of MMC in radiotherapy.
Edith Heinrich; Nikola Getoff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  58     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-06-17     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  244-8     Citation Subset:  IM    
Institute for Theoretical Chemistry and Structural Biology, The University of Vienna, Althanstr.14, A-1090 Vienna, Austria.
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MeSH Terms
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Escherichia coli / drug effects*,  growth & development
Gamma Rays
Mitomycin / pharmacology*,  radiation effects*
Thiamine / pharmacology
Vitamin E / pharmacology
Vitamins / pharmacology*,  radiation effects
beta Carotene / pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Vitamins; 1406-18-4/Vitamin E; 50-07-7/Mitomycin; 50-81-7/Ascorbic Acid; 59-43-8/Thiamine; 7235-40-7/beta Carotene

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