Document Detail

Mitogenic response to colony-stimulating factor 1.
MedLine Citation:
PMID:  1840317     Owner:  NLM     Status:  MEDLINE    
The proliferative effects of colony-stimulating factor 1 (CSF-1) on cells of the mononuclear phagocyte lineage are mediated by the CSF-1 receptor tyrosine kinase, which triggers intracellular signal transduction through multiple second messenger pathways. CSF-1 is required throughout G1 to stimulate both immediate- and delayed-early responses that ensure entry of macrophages into S phase. Because CSF-1 induces the expression of different sets of cellular genes during early and late G1, products of the immediate-early response might modulate the effects of ensuing receptor signals to facilitate G1 progression. Targets of the delayed-early response include novel cyclin genes that may play a role in S phase commitment.
C J Sherr
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  7     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:    1991 Nov-Dec
Date Detail:
Created Date:  1992-08-04     Completed Date:  1992-08-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  398-402     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN 38105.
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MeSH Terms
Cell Cycle / drug effects
Cell Differentiation / drug effects
Cell Division / drug effects
Growth Substances / physiology
Hematopoietic Stem Cells / drug effects*
Macrophage Colony-Stimulating Factor / genetics,  pharmacology,  physiology*
Macrophages / cytology
Mice, Mutant Strains / genetics
Models, Biological
Protein Processing, Post-Translational
Protein-Tyrosine Kinases / genetics,  physiology
Proto-Oncogene Proteins / physiology
Receptor, Macrophage Colony-Stimulating Factor / genetics,  physiology
Second Messenger Systems*
Transcription Factors / physiology
Reg. No./Substance:
0/Growth Substances; 0/Proto-Oncogene Proteins; 0/Transcription Factors; 81627-83-0/Macrophage Colony-Stimulating Factor; EC Kinases; EC, Macrophage Colony-Stimulating Factor

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