| Mitogenic response of cells in culture to demineralized bone matrix. | |
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MedLine Citation:
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PMID: 3164049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study the mitogenic effect of demineralized bone powder (DBP) on cells in tissue culture was evaluated. The cells studied have osteoblastic properties. At a DBP concentration of 100 micrograms/well, rat osteosarcoma cells (ROS) 17/2.8 cells, ROS 24/1 cells, and periosteal fibroblasts (POF) all showed a significant increase in proliferation in comparison to controls. The peak effect was on day two for ROS 17/2.8 (125% of control), on day three for ROS 24/1 (139% of control), and on day four for POF (145% of control). The results indicate that this in vitro system may be useful for evaluating the osteoinductive activity of DBP preparations. |
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Authors:
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D S Huang; R T Kao; A Shteyer; L Kaban |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Volume: 46 ISSN: 0278-2391 ISO Abbreviation: J. Oral Maxillofac. Surg. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-07-15 Completed Date: 1988-07-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206428 Medline TA: J Oral Maxillofac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 460-4 Citation Subset: AIM; D; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Matrix / metabolism, physiology* Cell Count Cell Division Culture Media Culture Techniques / methods Evaluation Studies as Topic Fibroblasts / physiology* Minerals / metabolism* Osteoblasts / physiology* Osteogenesis* Osteosarcoma Rats Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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DEO7679/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Minerals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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