Document Detail

Mitogenic effect of L-dopa on human periodontal ligament fibroblast cells.
MedLine Citation:
PMID:  12017179     Owner:  NLM     Status:  MEDLINE    
In cases of tooth avulsion, immediate replantation is the treatment of choice. In the event of any problem, the tooth should be stored in a medium that supports the periodontal ligament cell viability. Theoretically, mitotic promoting agents may be of use to preserve cell viability. It has previously been reported that levodopa (L-dopa) accelerates healing by increasing the growth hormone level. In this study, the direct effect of L-dopa was investigated on human periodontal ligament fibroblast (HPLF) cells. Cell culture methods were used to assess the potential mitogenic effect of L-dopa. Results show that in low concentrations of L-dopa (1 microgram/microl in this study), the number of HPLF cells were remarkably higher than the control group, and the number of viable cells were not affected by increasing the L-dopa concentration in the range of the study. These results suggest that L-dopa can also have a direct local effect on the growth of HPLF cells. These results may be of use clinically to increase the viability of HPLF cells in cases of an avulsed tooth preserved in storing medium.
Mandana Partovi; Ahmad Sadeghein; Ebrahim Azizi; S Nasser Ostad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endodontics     Volume:  28     ISSN:  0099-2399     ISO Abbreviation:  J Endod     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-17     Completed Date:  2002-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  D    
Faculty of Dentistry University of Babol, Teheran, Iran.
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MeSH Terms
Cells, Cultured
Coloring Agents
Dopamine Agents / pharmacology*
Fibroblasts / cytology,  drug effects
Levodopa / pharmacology*
Mitosis / drug effects*
Periodontal Ligament / cytology,  drug effects*
Tetrazolium Salts
Tissue Preservation / methods*
Reg. No./Substance:
0/Coloring Agents; 0/Dopamine Agents; 0/Levodopa; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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