Document Detail

Mitogenic activities for skin fibroblasts in the sera from untreated scleroderma patients at the early stage.
MedLine Citation:
PMID:  2596866     Owner:  NLM     Status:  MEDLINE    
Mitogenic activities for adult skin fibroblasts in 17 sera from untreated patients with scleroderma at the early stage were studied. Mitogenic activities in 10% test sera were measured by the [3H]-thymidine incorporation assay using confluent fibroblasts; there was no significant difference between scleroderma-affected and normal controls. Growth-stimulatory activities for subconfluent fibroblasts in 10% test sera were measured by increased cell numbers; again, there was no significant difference between scleroderma-affected and normal controls. There have been contradictory reports on growth-stimulatory activities in scleroderma sera; our data do not suggest the presence of a specific mitogen in scleroderma sera.
A Igarashi; K Takehara; Y Soma; K Kikuchi; Y Ishibashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatological research     Volume:  281     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  383-6     Citation Subset:  IM    
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Cell Division
Cells, Cultured
Fibroblasts / pathology
Growth Substances / blood
Middle Aged
Mitogens / blood*
Scleroderma, Systemic / blood*,  pathology
Skin / pathology*
Reg. No./Substance:
0/Growth Substances; 0/Mitogens

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