Document Detail


Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.
MedLine Citation:
PMID:  23020821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neurogenic niche within the subgranular zone (SGZ) of the dentate gyrus is a source of new neurons throughout life. Interestingly, SGZ proliferative capacity is regulated by both physiological and pathophysiological conditions. One outstanding question involves the molecular mechanisms that regulate both basal and inducible adult neurogenesis. Here, we examined the role of the MAPK-regulated kinases, mitogen- and stress-activated kinase (MSK)1 and MSK2. as regulators of dentate gyrus SGZ progenitor cell proliferation and neurogenesis. Under basal conditions, MSK1/2 null mice exhibited significantly reduced progenitor cell proliferation capacity and a corollary reduction in the number of doublecortin (DCX)-positive immature neurons. Strikingly, seizure-induced progenitor proliferation was totally blocked in MSK1/2 null mice. This blunting of cell proliferation in MSK1/2 null mice was partially reversed by forskolin infusion, indicating that the inducible proliferative capacity of the progenitor cell population was intact. Furthermore, in MSK1/2 null mice, DCX-positive immature neurons exhibited reduced neurite arborization. Together, these data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the SGZ.
Authors:
Yun-Sik Choi; Kate Karelina; Diego Alzate-Correa; Kari R Hoyt; Soren Impey; J Simon Arthur; Karl Obrietan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-25
Journal Detail:
Title:  Journal of neurochemistry     Volume:  123     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-01-10     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  676-88     Citation Subset:  IM    
Copyright Information:
Published 2012. This article is a US Government work and is in the public domain in the USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / cytology,  enzymology*
Animals
Cell Proliferation*
Dentate Gyrus / cytology,  enzymology
Immunohistochemistry
In Situ Nick-End Labeling
Mice
Mice, Knockout
Neural Stem Cells / enzymology*
Neurogenesis / physiology*
Ribosomal Protein S6 Kinases, 90-kDa / deficiency,  metabolism*
Grant Support
ID/Acronym/Agency:
MH086032/MH/NIMH NIH HHS; MH62335/MH/NIMH NIH HHS; NS066345/NS/NINDS NIH HHS; NS067409/NS/NINDS NIH HHS; R01 NS047176/NS/NINDS NIH HHS; R01 NS066345/NS/NINDS NIH HHS; R01 NS067409/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.11.1/Ribosomal Protein S6 Kinases, 90-kDa; EC 2.7.11.1/Rps6ka4 protein, mouse; EC 2.7.11.1/mitogen and stress-activated protein kinase 1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transverse myelitis secondary to melioidosis: a case report.
Next Document:  Refractory neuro-Behçet treated by tocilizumab: a case report.