| Mitogen-activated protein kinases in cerebral vasospasm after subarachnoid hemorrhage: a review. | |
| | |
MedLine Citation:
|
PMID: 21116928 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Mitogen-activated protein kinases (MAPKs) have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. The goal of this review is to bring together recent diverse data concerning the roles of MAPKs in cerebral vasospasm and to consider the future research. Emphasis Type="Italic">Method: A review of publications in the National Library of Medicine and National Institutes of Health database was conducted in August 2009 using specific keyword search terms pertaining to subarachnoid hemorrhage and MAPKs. Findings: There are nine in vitro studies and 17 in vivo studies published. Most of previous studies used MAPK inhibitors or their upstream molecule inhibitors, and showed that MAPK inhibitions prevented vasospasm. The MAPK cascade appears to interact with other signaling molecules, and MAPK may be an important final common pathway for the signaling transduction during cerebral vasospasm. However, the mechanism by which MAPK causes sustained vascular smooth muscle contraction remains unclear. In addition, the role of endogenous MAPK inhibitors, MAPK phosphatases, has not been investigated in cerebral vasospasm. Conclusions: The experimental data support the causative role of MAPK in cerebral vasospasm and warrant further research. |
| | |
Authors:
|
Hidenori Suzuki; Yu Hasegawa; Kenji Kanamaru; John H Zhang |
Related Documents
:
|
8609418 - Il-13 induces phosphorylation and activation of jak2 janus kinase in human colon carcin... 17717068 - Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinase... 17070518 - 2-aminopurine inhibits leptin receptor signal transduction. 16934228 - Suppression of il-1beta expression by the jak 2 inhibitor ag490 in cerulein-stimulated ... 23608488 - Il-4 inhibition of il-1 induced matrix metalloproteinase-3 (mmp-3) expression in human ... 16362038 - Novel roles of akt and mtor in suppressing tgf-beta/alk5-mediated smad3 activation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta neurochirurgica. Supplement Volume: 110 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: Austria |
Other Details:
|
Languages: eng Pagination: 133-9 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA, 92354, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebral microdialysis in acutely brain-injured patients with spreading depolarizations.
Next Document: Association of apolipoprotein e polymorphisms with cerebral vasospasm after spontaneous subarachnoid...