Document Detail

Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction.
MedLine Citation:
PMID:  11472310     Owner:  NLM     Status:  MEDLINE    
Exercise has numerous growth and metabolic effects in skeletal muscle, including changes in glycogen metabolism, glucose and amino acid uptake, protein synthesis and gene transcription. However, the mechanism(s) by which exercise regulates intracellular signal transduction to the transcriptional machinery in the nucleus, thus modulating gene expression, is largely unknown. This review will provide insight on potential intracellular signalling mechanisms by which muscle contraction/exercise leads to changes in gene expression. Mitogen-activated protein kinase (MAPK) cascades are associated with increased transcriptional activity. The MAPK family members can be separated into distinct parallel pathways including the extracellular signal-regulated kinase (ERK) 1/2, the stress-activated protein kinase cascades (SAPK1/JNK and SAPK2/p38) and the extracellular signal-regulated kinase 5 (ERK5). Acute exercise elicits signal transduction via MAPK cascades in direct response to muscle contraction. Thus, MAPK pathways appear to be potential physiological mechanisms involved in the exercise-induced regulation of gene expression in skeletal muscle.
U Widegren; J W Ryder; J R Zierath
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  172     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-26     Completed Date:  2001-10-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-38     Citation Subset:  IM    
Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Exercise / physiology*
Mitogen-Activated Protein Kinases / metabolism*
Muscle Contraction / physiology
Muscle, Skeletal / physiology*
Physical Exertion / physiology*
Signal Transduction / physiology*
Reg. No./Substance:
EC Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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