Document Detail


Mitochondrial water in myocardial ischemia: investigation with nuclear magnetic resonance.
MedLine Citation:
PMID:  6246584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular hydration may be one of the first mechanisms to alter function in the mitochondria, which are vital to the energy-transducing process in heart muscle.
Authors:
L H Michael; P Seitz; J McMillin-Wood; D Chang; C Hazlewood; M L Entman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  208     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1267-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Fractionation / methods
Coronary Disease / metabolism*,  pathology
Dogs
Magnetic Resonance Spectroscopy
Mitochondria, Heart / metabolism*
Protons
Water / metabolism*
Chemical
Reg. No./Substance:
0/Protons; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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