| Mitochondrial structure and function in acute myocardial ischemic injury. | |
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MedLine Citation:
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PMID: 1269093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in both the structure and function of mitochondria occur in the dog heart as a consequence of severe ischemia produced by acute coronary occlusion. Brief periods of severe ischemia (reversible injury) produced no significant change in mitochondrial ultrastructure and no defects in pyruvate or succinate metabolism. However, periods of ischemia of 40-60 minutes' duration (irreversible injury) produced striking structural changes including swelling, an increase in matrix space, disorganization of cristae, and the appearance of amorphous matrix densities. After 60 minutes of severe ischemia, one or more amorphous densities were present in each mitochondrial profile. These osmiophilic structures contained lipid but have not been characterized further. Their presence was typical of the irreversible state. Mitochondria of irreversibly injured cells were fragile, and consequently were more difficult to isolate than mitochondria of control tissue. Furthermore, after isolation from tissue injured by 60 minutes of ischemia, they showed markedly defective function. |
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Authors:
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R B Jennings; C E Ganote |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation research Volume: 38 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1976 May |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: I80-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / pathology*, physiopathology Disease Models, Animal Dogs Mitochondria, Muscle / metabolism, ultrastructure* Mitochondrial Swelling Myocardium / metabolism, ultrastructure* Oxygen Consumption Pyruvates / metabolism Succinate Dehydrogenase / metabolism Succinates / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Pyruvates; 0/Succinates; EC 1.3.99.1/Succinate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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