Document Detail


Mitochondrial, sarcoplasmic membrane integrity and protein degradation in heart and skeletal muscle in exercised rats.
MedLine Citation:
PMID:  12600679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several different exercise regimens varied in the severity of tissue damage induced. Therefore, this study investigated the effects of a single bout of exercise versus endurance training in heart and skeletal muscles with different predominant fiber types on indices of mitochondrial, endoplasmic reticulum (ER) integrity and protein degradation. Male Wistar rats performed different treadmill exercise protocols: exhaustive, maximal exhaustive, eccentric, training and exhaustive exercise after training. The maximal and eccentric exercises resulted in a significant loss of integrity of the sarcoplasmic and ER muscle, while no changes were observed in cardiac muscle. Mitochondrial membrane fluidity measured by the fluorescence polarization method was significantly increased post-acute exercises in heart and oxidative muscles. Regular exercise can stabilize and preserve the viscoelastic nature of mitochondrial membranes in both tissues. The highest increase in carbonyl content was obtained in heart after exhaustive exercise protocol, from 1+/-0.1 to 3.6+/-0.14 nmol mg protein(-1), such increase were not found after regular exercise with values significantly decreased. Nitrate heart levels showed attenuated generation of nitric oxide after training. Muscle protein oxidation was produced in all exhaustive exercises including eccentric exercise.
Authors:
Andrea C Perez; Antonio C Cabral de Oliveira; Emma Estevez; Antonio J Molina; Julio G Prieto; Ana I Alvarez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  134     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-25     Completed Date:  2003-10-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Leon, Leon 24071, Spain.
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MeSH Terms
Descriptor/Qualifier:
Alkaline Phosphatase / metabolism
Animals
Carbonic Acid / metabolism
Fluorescence Polarization / methods
Intracellular Membranes / enzymology,  physiology*
Male
Membrane Fluidity / physiology*
Mitochondria, Heart / metabolism*
Muscle, Skeletal / metabolism
Myocardium / metabolism
Nitrates / metabolism
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology
Rats
Rats, Wistar
Sarcoplasmic Reticulum / metabolism*
Chemical
Reg. No./Substance:
0/Nitrates; 463-79-6/Carbonic Acid; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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