| Mitochondrial respiratory chain activity in skeletal muscle from patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 8232939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Different abnormalities in mitochondrial electron transport chain activity have been demonstrated in muscle and other tissues of patients with idiopathic Parkinson's disease (PD). We studied eight Spanish patients with PD to evaluate the functional activity of the electron transport chain in muscle mitochondria from patients of this country. We found lower complex I activity (nmol.min-1.mg-1) in patients (245.8 +/- 42.8) than in controls (331.6 +/- 60.1) (p = 0.004) and lower complex IV activity in patients (46.1 +/- 9) than in controls (144.1 +/- 42.3) (p = 0.00001). Complex V activity was also decreased in two patients and complex II and III activities were normal in all of them. Although these results strongly suggest an alteration in mitochondrial DNA in PD, the various electron transport chain defects in different tissues seem to be nonspecific. |
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Authors:
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F Cardellach; M J Martí; J Fernández-Solá; C Marín; J B Hoek; E Tolosa; A Urbano-Márquez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 43 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-12-20 Completed Date: 1993-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2258-62 Citation Subset: AIM; IM |
Affiliation:
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Department of General Internal Medicine, Hospital Clinic i Provincial, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Electron Transport Female Humans Male Middle Aged Mitochondria, Muscle / metabolism*, pathology Oxidative Phosphorylation Parkinson Disease / metabolism*, pathology Spain |
| Comments/Corrections | |
Comment In:
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Neurology. 1993 Nov;43(11):2170-2
[PMID:
8232923
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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