| Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease. | |
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MedLine Citation:
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PMID: 20679415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Under hypoxic conditions, mitochondria can represent a threat to the cell because of their capacity to generate toxic reactive oxygen species (ROS). However, cardiomyocytes are equipped with an oxygen-sensing pathway that involves prolyl hydroxylase oxygen sensors and hypoxia-inducible factors (HIFs), which induces a tightly regulated programme to keep ischaemic mitochondrial activity under control. The aim of this review is to provide an update on the pathways leading to mitochondrial reprogramming, which occurs in the myocardium during ischaemia, with particular emphasis on those induced by HIF activation. We start by studying the mechanisms of mitochondrial damage during ischaemia and upon reperfusion, highlighting the importance of the formation of the mitochondrial permeability transition pore during reperfusion and its consequences for cardiomyocyte survival. Next, we analyse hypoxia-induced metabolic reprogramming through HIF and its important consequences for mitochondrial bioenergetics, as well as the phenomenon known as the hibernating myocardium. Subsequently, we examine the mechanisms underlying ischaemic preconditioning, focusing, in particular, on those that involve the HIF pathway, such as adenosine signalling, sub-lethal ROS generation, and nitric oxide production. Finally, the role of the mitochondrial uncoupling proteins in ischaemia tolerance is discussed. |
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Authors:
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Susana Cadenas; Julián Aragonés; Manuel O Landázuri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-08-02 |
Journal Detail:
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Title: Cardiovascular research Volume: 88 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2011-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
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Languages: eng Pagination: 219-28 Citation Subset: IM |
Affiliation:
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Servicio de Inmunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa , Diego de León 62, 28006 Madrid, Spain. susana.cadenas@salud.madrid.org |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Hypoxia Humans Hypoxia-Inducible Factor 1 / metabolism Ion Channels / metabolism Ischemic Preconditioning, Myocardial* Mitochondria, Heart / metabolism*, pathology Mitochondrial Proteins / metabolism Myocardial Ischemia / metabolism, pathology, therapy* Myocardial Reperfusion Injury / metabolism, pathology, prevention & control* Myocardium / metabolism*, pathology Oxygen / metabolism* Procollagen-Proline Dioxygenase / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1; 0/Ion Channels; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein; 7782-44-7/Oxygen; EC 1.14.11.2/Procollagen-Proline Dioxygenase |
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