Document Detail

Mitochondrial regulation of cell survival and death during low-oxygen conditions.
MedLine Citation:
PMID:  19580395     Owner:  NLM     Status:  MEDLINE    
Mitochondria can initiate cell death or activate genes that promote cell survival in response to low oxygen. The BCL-2 family of proteins regulate cell death in response to anoxia (0-0.5% O2). By contrast, under hypoxia (0.5-3% O2), mitochondrial oxidative stress activates hypoxia-inducible factors (HIFs) to promote cell survival. In this review, we discuss how mitochondria, BCL-2 proteins, and HIFs are crucial for cellular responses to low oxygen.
Colleen M Snyder; Navdeep S Chandel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  11     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2009-12-30     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2673-83     Citation Subset:  IM    
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School , Chicago, Illinois, USA.
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MeSH Terms
Cell Death / physiology
Cell Hypoxia / physiology
Cell Survival / physiology
Hypoxia-Inducible Factor 1 / metabolism,  physiology
Mitochondria / metabolism*
Models, Biological
Oxidative Stress / physiology*
Proto-Oncogene Proteins c-bcl-2 / metabolism,  physiology
Grant Support
R01CA123067-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1; 0/Proto-Oncogene Proteins c-bcl-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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