| Mitochondrial regulation of cell survival and death during low-oxygen conditions. | |
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MedLine Citation:
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PMID: 19580395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitochondria can initiate cell death or activate genes that promote cell survival in response to low oxygen. The BCL-2 family of proteins regulate cell death in response to anoxia (0-0.5% O2). By contrast, under hypoxia (0.5-3% O2), mitochondrial oxidative stress activates hypoxia-inducible factors (HIFs) to promote cell survival. In this review, we discuss how mitochondria, BCL-2 proteins, and HIFs are crucial for cellular responses to low oxygen. |
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Authors:
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Colleen M Snyder; Navdeep S Chandel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 11 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-16 Completed Date: 2009-12-30 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 2673-83 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School , Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death / physiology Cell Hypoxia / physiology Cell Survival / physiology Humans Hypoxia-Inducible Factor 1 / metabolism, physiology Mitochondria / metabolism* Models, Biological Oxidative Stress / physiology* Proto-Oncogene Proteins c-bcl-2 / metabolism, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01CA123067-03/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1; 0/Proto-Oncogene Proteins c-bcl-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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