| Mitochondrial regulation of cell cycle and proliferation. | |
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MedLine Citation:
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PMID: 21967640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into ancient archaea species. During evolution, mitochondria lost most of the prokaryotic bacterial genes and only conserved a small fraction including those encoding 13 proteins of the respiratory chain. In this process, many functions were transferred to the host cells, but mitochondria gained a central role in the regulation of cell proliferation and apoptosis, and in the modulation of metabolism; accordingly, defective organelles contribute to cell transformation and cancer, diabetes, and neurodegenerative diseases. Most cell and transcriptional effects of mitochondria depend on the modulation of respiratory rate and on the production of hydrogen peroxide released into the cytosol. The mitochondrial oxidative rate has to remain depressed for cell proliferation; even in the presence of O₂, energy is preferentially obtained from increased glycolysis (Warburg effect). In response to stress signals, traffic of pro- and antiapoptotic mitochondrial proteins in the intermembrane space (B-cell lymphoma-extra large, Bcl-2-associated death promoter, Bcl-2 associated X-protein and cytochrome c) is modulated by the redox condition determined by mitochondrial O₂ utilization and mitochondrial nitric oxide metabolism. In this article, we highlight the traffic of the different canonical signaling pathways to mitochondria and the contributions of organelles to redox regulation of kinases. Finally, we analyze the dynamics of the mitochondrial population in cell cycle and apoptosis. |
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Authors:
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Valeria Gabriela Antico Arciuch; María Eugenia Elguero; Juan José Poderoso; María Cecilia Carreras |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-01-13 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 16 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-07-25 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 1150-80 Citation Subset: IM |
Affiliation:
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Laboratory of Oxygen Metabolism, University of Buenos Aires, University Hospital, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Death Cell Proliferation Humans Mitochondria / physiology* Oxidation-Reduction Phosphotransferases / metabolism Reactive Oxygen Species / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; EC 2.7.-/Phosphotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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