Document Detail


Mitochondrial regulation of cell cycle and proliferation.
MedLine Citation:
PMID:  21967640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into ancient archaea species. During evolution, mitochondria lost most of the prokaryotic bacterial genes and only conserved a small fraction including those encoding 13 proteins of the respiratory chain. In this process, many functions were transferred to the host cells, but mitochondria gained a central role in the regulation of cell proliferation and apoptosis, and in the modulation of metabolism; accordingly, defective organelles contribute to cell transformation and cancer, diabetes, and neurodegenerative diseases. Most cell and transcriptional effects of mitochondria depend on the modulation of respiratory rate and on the production of hydrogen peroxide released into the cytosol. The mitochondrial oxidative rate has to remain depressed for cell proliferation; even in the presence of O₂, energy is preferentially obtained from increased glycolysis (Warburg effect). In response to stress signals, traffic of pro- and antiapoptotic mitochondrial proteins in the intermembrane space (B-cell lymphoma-extra large, Bcl-2-associated death promoter, Bcl-2 associated X-protein and cytochrome c) is modulated by the redox condition determined by mitochondrial O₂ utilization and mitochondrial nitric oxide metabolism. In this article, we highlight the traffic of the different canonical signaling pathways to mitochondria and the contributions of organelles to redox regulation of kinases. Finally, we analyze the dynamics of the mitochondrial population in cell cycle and apoptosis.
Authors:
Valeria Gabriela Antico Arciuch; María Eugenia Elguero; Juan José Poderoso; María Cecilia Carreras
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-13
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  16     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-07-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1150-80     Citation Subset:  IM    
Affiliation:
Laboratory of Oxygen Metabolism, University of Buenos Aires, University Hospital, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle*
Cell Death
Cell Proliferation
Humans
Mitochondria / physiology*
Oxidation-Reduction
Phosphotransferases / metabolism
Reactive Oxygen Species / metabolism
Signal Transduction
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; EC 2.7.-/Phosphotransferases
Comments/Corrections

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