| Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. | |
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MedLine Citation:
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PMID: 16326395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The precise control of the cell cycle requires regulation by many intrinsic and extrinsic factors. Whether the metabolic status of the cell exerts a direct control over cell cycle checkpoints is not well understood. We isolated a mutation, tenured (tend), in a gene encoding cytochrome oxidase subunit Va. This mutation causes a drop in intracellular ATP to levels sufficient to maintain cell survival, growth, and differentiation, but not to enable progression through the cell cycle. Analysis of this gene in vivo and in cell lines shows that a specific pathway involving AMPK and p53 is activated that causes elimination of Cyclin E, resulting in cell cycle arrest. We demonstrate that in multiple tissues the mitochondrion has a direct and specific role in enforcing a G1-S cell cycle checkpoint during periods of energy deprivation. |
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Authors:
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Sudip Mandal; Preeta Guptan; Edward Owusu-Ansah; Utpal Banerjee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Developmental cell Volume: 9 ISSN: 1534-5807 ISO Abbreviation: Dev. Cell Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-01-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 843-54 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cell, and Developmental Biology, Department of Biological Chemistry and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AMP-Activated Protein Kinases Adenosine Triphosphate / metabolism Animals Animals, Genetically Modified Cell Differentiation Cell Proliferation Cell Survival Cyclin E / metabolism Drosophila melanogaster / genetics, growth & development*, metabolism Electron Transport Complex IV / genetics*, metabolism Female G1 Phase* Male Mitochondria / metabolism* Multienzyme Complexes / metabolism Mutation* Protein-Serine-Threonine Kinases / metabolism S Phase* Tumor Suppressor Protein p53 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01-EY08152/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyclin E; 0/Multienzyme Complexes; 0/Tumor Suppressor Protein p53; 56-65-5/Adenosine Triphosphate; EC 1.9.3.1/Electron Transport Complex IV; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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