Document Detail

Mitochondrial permeability transitions: how many doors to the house?
MedLine Citation:
PMID:  15620364     Owner:  NLM     Status:  MEDLINE    
The inner mitochondrial membrane is famously impermeable to solutes not provided with a specific carrier. When this impermeability is lost, either in a developmental context or under stress, the consequences for the cell can be far-reaching. Permeabilization of isolated mitochondria, studied since the early days of the field, is often discussed as if it were a biochemically well-defined phenomenon, occurring by a unique mechanism. On the contrary, evidence has been accumulating that it may be the common outcome of several distinct processes, involving different proteins or protein complexes, depending on circumstances. A clear definition of this putative variety is a prerequisite for an understanding of mitochondrial permeabilization within cells, of its roles in the life of organisms, and of the possibilities for pharmacological intervention.
Mario Zoratti; Ildikò Szabò; Umberto De Marchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1706     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  40-52     Citation Subset:  IM    
CNR Institute of Neuroscience, Biomembranes Section, Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy.
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MeSH Terms
Calcium / metabolism
Cyclophilins / metabolism
Intracellular Membranes / metabolism*
Mitochondria / metabolism*
Mitochondrial ADP, ATP Translocases / metabolism
Models, Molecular
Porins / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism
bcl-2-Associated X Protein
Reg. No./Substance:
0/Ligands; 0/Porins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 7440-70-2/Calcium; 9068-80-8/Mitochondrial ADP, ATP Translocases; EC 5.2.1.-/Cyclophilins; EC D

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