| Mitochondrial pathway of apoptosis in the hepatopancreas of the freshwater crab Sinopotamon yangtsekiense exposed to cadmium. | |
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MedLine Citation:
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PMID: 21831345 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cadmium (Cd) is one of the most common toxic metals in water. To investigate the mechanism of Cd-induced apoptosis in the hepatopancreas, freshwater crabs Sinopotamon yangtsekiense were exposed to 0, 3.56, 7.12, 14.25, 28.49 and 56.98mg/L Cd for 48h. After a 48h exposure, apoptosis and necroptosis were apparent in the group exposed to 28.49mg/L Cd and only one case of necrosis was observed in the highest concentration of Cd. Electronic microscopy revealed chromatin condensation under nuclear membrane and mitochondrial membrane rupture in 14.25 and 28.49mg/L Cd treatment groups. Brown colored apoptotic cells were detected with the TUNEL test in all Cd-treatment groups. The AI in 56.98mg/L group was 1.4-fold greater than that in crabs exposed to 14.25mg/L Cd. Caspase-9, caspase-3, SDH and Ca(2+)-ATPase activities increased with increasing Cd concentration. However, the activities of caspase-8 and LDH did not change significantly compared with control group. These results implied that Cd induced apoptosis in the hepatopancreas occurs through a mitochondrial pathway. |
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Authors:
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Dongmei Liu; Bo Yan; Jian Yang; Wenwen Lei; Lan Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-23 |
Journal Detail:
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Title: Aquatic toxicology (Amsterdam, Netherlands) Volume: 105 ISSN: 1879-1514 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500246 Medline TA: Aquat Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: 394-402 Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of the Bio-effect and Molecular Mechanism on Classical Environmental Pollutants, School of Life Science, Shanxi University, 96 Wucheng Road, Taiyuan 030006, Shanxi Province, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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