| Mitochondrial network size scaling in budding yeast. | |
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MedLine Citation:
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PMID: 23139336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance. |
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Authors:
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Susanne M Rafelski; Matheus P Viana; Yi Zhang; Yee-Hung M Chan; Kurt S Thorn; Phoebe Yam; Jennifer C Fung; Hao Li; Luciano da F Costa; Wallace F Marshall |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 338 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-09 Completed Date: 2012-12-03 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 822-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, University of California-San Francisco (UCSF), San Francisco, CA, USA. susanner@uci.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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G1 Phase Microscopy, Confocal Mitochondria / metabolism*, ultrastructure* Mitochondrial Size* Saccharomyces cerevisiae / cytology, growth & development*, ultrastructure* Saccharomyces cerevisiae Proteins / genetics, metabolism rab GTP-Binding Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5R01GM097213-02/GM/NIGMS NIH HHS; P50GM081879/GM/NIGMS NIH HHS; R01 GM097017/GM/NIGMS NIH HHS; R01GM026259/GM/NIGMS NIH HHS; R01GM070808/GM/NIGMS NIH HHS; R01GM097017/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Saccharomyces cerevisiae Proteins; 0/Ypt11 protein, S cerevisiae; EC 3.6.1.-/rab GTP-Binding Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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