Document Detail


Mitochondrial network size scaling in budding yeast.
MedLine Citation:
PMID:  23139336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance.
Authors:
Susanne M Rafelski; Matheus P Viana; Yi Zhang; Yee-Hung M Chan; Kurt S Thorn; Phoebe Yam; Jennifer C Fung; Hao Li; Luciano da F Costa; Wallace F Marshall
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  338     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2012-12-03     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  822-4     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, University of California-San Francisco (UCSF), San Francisco, CA, USA. susanner@uci.edu
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MeSH Terms
Descriptor/Qualifier:
G1 Phase
Microscopy, Confocal
Mitochondria / metabolism*,  ultrastructure*
Mitochondrial Size*
Saccharomyces cerevisiae / cytology,  growth & development*,  ultrastructure*
Saccharomyces cerevisiae Proteins / genetics,  metabolism
rab GTP-Binding Proteins / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
5R01GM097213-02/GM/NIGMS NIH HHS; P50GM081879/GM/NIGMS NIH HHS; R01 GM097017/GM/NIGMS NIH HHS; R01GM026259/GM/NIGMS NIH HHS; R01GM070808/GM/NIGMS NIH HHS; R01GM097017/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Saccharomyces cerevisiae Proteins; 0/Ypt11 protein, S cerevisiae; EC 3.6.1.-/rab GTP-Binding Proteins
Comments/Corrections

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