Document Detail


Mitochondrial network in the heart.
MedLine Citation:
PMID:  22752872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondria are subcellular organelles that provide energy for the cell. They form a dynamic tubular network and play an important role in maintaining the cell function and integrity. Heart is a powerful organ that supplies the motivation for circulation, thereby requiring large amounts of energy. Thus, the healthiness of cardiomyocytes and mitochondria is necessary for the normal cardiac function. Mitochondria not only lie in the center of the cell apoptotic pathway, but also are the major source of reactive oxygen species (ROS) generation. Mitochondrial morphological change includes fission and fusion that are regulated by a large number of proteins. In this review we discuss the regulators of mitochondrial fission/fusion and their association with cell apoptosis, autophagy and ROS production in the heart.
Authors:
Qian Li; Lu-Yu Zhou; Gui-Feng Gao; Jian-Qin Jiao; Pei-Feng Li
Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-01
Journal Detail:
Title:  Protein & cell     Volume:  3     ISSN:  1674-8018     ISO Abbreviation:  Protein Cell     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2013-06-27     Revised Date:  2014-03-13    
Medline Journal Info:
Nlm Unique ID:  101532368     Medline TA:  Protein Cell     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  410-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Heart*
Humans
Mitochondria, Heart / metabolism*
Myocardium / cytology*,  metabolism
Reactive Oxygen Species / metabolism
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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