| Mitochondrial myopathy presenting as rhabdomyolysis. | |
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MedLine Citation:
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PMID: 21771927 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 37-year-old white woman presented with acute bilateral hamstring pain after hiking. She had a creatine kinase level of 11,144 U/L. Rhabdomyolysis was diagnosed and the patient was admitted for intravenous fluid hydration. The patient continued to have exercise-induced myalgias and elevations in her creatine kinase level. Rheumatologic causes were ruled out and results from electromyogram testing were nondiagnostic. A muscle biopsy revealed a mitochondrial myopathy. The 22 mitochondrial DNA and transfer RNA genes were sequenced. An A-to-G transition was found at nucleotide position 4281 in the transfer RNA isoleucine gene. The patient was placed on a regimen of riboflavin, vitamin C, and coenzyme Q10, which provided mild relief. The patient returned to the emergency department 2 more times after vigorous exercise, with creatine kinase levels as high as 2800 U/L. At last follow-up, the patient was using a fentanyl citrate transdermal patch, which enabled her to perform moderate exercise without pain. |
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Authors:
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David C Patchett; Michael L Grover |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the American Osteopathic Association Volume: 111 ISSN: 1945-1997 ISO Abbreviation: J Am Osteopath Assoc Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503065 Medline TA: J Am Osteopath Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 404-5 Citation Subset: IM |
Affiliation:
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Midwestern University/Arizona College of Osteopathic Medicine, 19389 N 59th Ave, Glendale, AZ 85308-6500. dpatchett@midwestern.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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