Document Detail


Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes with deterioration during pregnancy.
MedLine Citation:
PMID:  9804089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a 31-year-old woman who developed myopathy and neuropathy during pregnancy. She was diagnosed as having mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). A T-to-C transition mutation at nucleotide position 3271 was detected in the mitochondrial gene. Her symptoms subsided spontaneously and she delivered a male infant at 38 weeks of gestation. Prior reports on mitochondrial diseases with pregnancy are very rare, probably because of the early onset of the disease. The metabolic changes during pregnancy increase the stress on the mitochondrial function, particularly in patients with impaired mitochondrial function. Therefore pregnancy can aggravate mitochondrial diseases.
Authors:
T Yanagawa; H Sakaguchi; T Nakao; H Sasaki; G Matsumoto; T Sanke; K Nanjo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  37     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  780-3     Citation Subset:  IM    
Affiliation:
First Department of Medicine, Wakayama University of Medical Science.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Codon / genetics
DNA, Mitochondrial / genetics
Female
Humans
Infant, Newborn
MELAS Syndrome* / diagnosis,  epidemiology,  genetics
Male
Point Mutation
Pregnancy
Pregnancy Complications* / diagnosis
RNA, Transfer, Leu / genetics*
Stress, Physiological / metabolism
Chemical
Reg. No./Substance:
0/Codon; 0/DNA, Mitochondrial; 0/RNA, Transfer, Leu

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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