Document Detail

Mitochondrial myopathy caused by clevudine therapy in chronic hepatitis B patients.
MedLine Citation:
PMID:  19712273     Owner:  NLM     Status:  In-Data-Review    
As a pyrimidine analog with potent and sustained antiviral activity against hepatitis B virus, clevudine has been known to have no effect on mitochondrial structure, DNA content, or function. There is little information on the side effects of clevudine, which has not been approved for the treatment of chronic hepatitis B outside of South Korea. We report here two cases of chronic hepatitis B patients who experienced mitochondrial myopathy after clevudine medication. These cases raise concerns about the safety profile of clevudine for the treatment of chronic hepatitis B.
Won Young Tak; Soo Young Park; Min Kyu Jung; Seong Woo Jeon; Chang Min Cho; Young Oh Kweon; Sung Kook Kim; Yong Hwan Choi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  39     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  944-7     Citation Subset:  -    
Department of Internal Medicine, Liver Research Institute, Graduate School of Medicine, Kyungpook National University, Daegu, Korea.
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