| Mitochondrial membrane potential profile and its correlation with increasing sperm motility. | |
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MedLine Citation:
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PMID: 21507394 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate sperm mitochondrial integrity through analysis of mitochondrial membrane potential (Δψ) and to correlate the energy status with variations in sperm motility. DESIGN: Experimental study. SETTING: Seminology Laboratory, University of Rome, Italy. PATIENT(S): Two hundred thirteen semen samples from the same number of patients, divided into two groups on the basis of their motility: group A, 185 samples with linear motility and group B, 28 samples with nonlinear motility. INTERVENTION(S): Evaluation of sperm motility. MAIN OUTCOME MEASURE(S): Sperm mitochondrial integrity evaluated with a fluorimetric method using the cationic lipophilic stain JC-1. RESULT(S): The mean FL2 (percentage of sperm with high and low ∆ψ) for group A was 46.19 ± 23.25 and for group B, it was 48.32 ± 24.43. There was no significant difference between the groups. There was a positive correlation between both FL2 and linear motility and FL2 and sperm vitality in group A; both correlations were statistically significant. In group B, there was a positive correlation between FL2 and nonlinear motility and FL2 and sperm vitality; again, both correlations were statistically significant. CONCLUSION(S): Our data reveal a positive correlation between total motility and Δψ, suggesting that sperm motility may be dependent on the functional integrity of the mitochondria. |
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Authors:
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Donatella Paoli; Mariagrazia Gallo; Flavio Rizzo; Elisabetta Baldi; Sandro Francavilla; Andrea Lenzi; Francesco Lombardo; Loredana Gandini |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-19 |
Journal Detail:
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Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Seminology-Semen Bank, Department of Experimental Medicine, University of Rome "La Sapienza," Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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