| Mitochondrial localization of viral proteins as a means to subvert host defense. | |
| | |
MedLine Citation:
|
PMID: 20807553 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Viruses have developed a battery of distinct strategies to overcome the very sophisticated defense mechanisms of the infected host. Throughout the process of pathogen-host co-evolution, viruses have therefore acquired the capability to prevent host cell apoptosis because elimination of infected cells via apoptosis is one of the most ancestral defense mechanism against infection. Conversely, induction of apoptosis may favor viral dissemination as a result of the dismantlement of the infected cells. Mitochondria have been long recognized for their key role in the modulation of apoptosis but more recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling as illustrated by the identification of MAVS. Thus, it is therefore not surprising that this organelle represents a recurrent target for viruses, aiming to manipulate the fate of the infected host cell or to inhibit innate immune response. In this review, we highlight the viral proteins that are specifically targeted to the mitochondria to subvert host defense. This article is part of a Special Issue entitled Mitochondria: the deadly organelle. |
| | |
Authors:
|
Céline Castanier; Damien Arnoult |
Related Documents
:
|
18981083 - Cutting edge: experimentally induced immune activation in natural hosts of simian immun... 15448373 - The glycoprotein of a fish rhabdovirus profiles the virus-specific t-cell repertoire in... 11149563 - The role of chemokines and chemokine receptors in mucosal inflammation. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-31 |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: 1813 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 575-83 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical ...
Next Document: Detection of metallo-?-lactamase genes in clinical specimens by a commercial multiplex PCR system.