Document Detail


Mitochondrial introgressions into the nuclear genome of the domestic cat.
MedLine Citation:
PMID:  17660503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Translocation of mtDNA into the nuclear genome, also referred to as numt, was first reported in the domestic cat (Felis catus) by Lopez et al. (1994). The Lopez-numt consisted of a translocation of 7.9 kbp of mtDNA that inserted into the domestic cat chromosome D2 around 1.8 million years ago. More than a decade later, the release of the domestic cat whole-genome shotgun sequences (1.9x coverage) provides the resource to obtain more comprehensive insight into the extent of mtDNA transfer over time in the domestic cat genome. MegaBLAST searches revealed that the cat genome harbors a wide variety of numts (298 320 bp), one-third of which likely correspond to the Lopez-numt tandem repeat, whereas the remaining numts are probably derived from multiple independent insertions, which in some cases were followed by segmental duplication after insertion in the nucleus. Numts were detected across most cat chromosomes, but the number of numts assigned to chromosomes is underestimated due to the relatively high number of numt sequences with insufficient flanking sequence to map. The catalog of cat numts provides a valuable resource for future studies in Felidae species, including its use as a tool to avoid numt contaminations that may confound population genetics and phylogenetic studies.
Authors:
Agostinho Antunes; Joan Pontius; Maria João Ramos; Stephen J O'Brien; Warren E Johnson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2007-07-28
Journal Detail:
Title:  The Journal of heredity     Volume:  98     ISSN:  0022-1503     ISO Abbreviation:  J. Hered.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375373     Medline TA:  J Hered     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
Affiliation:
Laboratory of Genomic Diversity, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA. aantunes@ncifcrf.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Domestic / genetics
Cats / genetics*
Cell Nucleus / genetics*
Chromosome Mapping
DNA, Mitochondrial / genetics*
Genome*
Hyaenidae / genetics
Panthera / genetics
Translocation, Genetic
Grant Support
ID/Acronym/Agency:
N01-CO-12400/CO/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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