| Mitochondrial injury and protection in ischemic pre- and postconditioning. | |
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MedLine Citation:
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PMID: 20615074 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of the mitochondrial permeability transition pore. The formation of reactive oxygen species in mitochondria will be analyzed with regard to factors controlling mitochondrial permeability transition pore opening. Finally, these mitochondrial processes are analyzed with respect to cardioprotection afforded by ischemic pre- and postconditioning. Antioxid. Redox Signal. 14, 881-891. |
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Authors:
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Fabio Di Lisa; Marcella Canton; Andrea Carpi; Nina Kaludercic; Roberta Menabò; Sara Menazza; Martina Semenzato |
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Publication Detail:
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Type: Journal Article Date: 2010-11-30 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 14 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 881-91 Citation Subset: IM |
Affiliation:
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1 Department of Biomedical Sciences, University of Padova , Padova, Italy . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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