Document Detail


Mitochondrial hexokinase and cardioprotection of the intact heart.
MedLine Citation:
PMID:  19347573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of hexokinase with mitochondria has emerged as a powerful mechanism in protecting many cell types against cell death. However, the role of mitochondrial hexokinase (mitoHK) in cardiac ischemia-reperfusion injury has as of yet received little attention. In this review we examine whether increased binding of hexokinase to the mitochondrion is also an integral component of cardioprotective signalling. We discuss observations in cardiac mitochondrial activation that directed us to the hypothesis of hexokinase cellular redistribution with reversible, cardioprotective ischemia, summarize the data showing that many cardioprotective interventions, such as ischemic preconditioning, insulin, morphine and volatile anesthetics, increase mitochondrial hexokinase binding within the intact heart, and discuss similarities between mitochondrial hexokinase association and ischemic preconditioning. Although most data indicate that mitochondrial hexokinase may indeed be an integral part of cardioprotection, a definitive proof for a causal relation between the amount of mitoHK and cardiac ischemia-reperfusion injury in the intact heart is eagerly awaited. When such relationship is indeed observed, the association of hexokinase with mitochondria will offer an opportunity to develop new therapies to combat ischemic cardiac diseases.
Authors:
C J Zuurbier; K M A Smeele; O Eerbeek
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of bioenergetics and biomembranes     Volume:  41     ISSN:  1573-6881     ISO Abbreviation:  J. Bioenerg. Biomembr.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701859     Medline TA:  J Bioenerg Biomembr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Affiliation:
Laboratory of Experimental Intensive Care & Anesthesiology (L.E.I.C.A.), Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. c.j.zuurbier@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / therapeutic use
Hexokinase / metabolism*
Humans
Ischemic Preconditioning, Myocardial*
Mitochondria, Heart / enzymology*
Myocardial Reperfusion Injury / enzymology*,  therapy
Myocardium / enzymology*
Signal Transduction*
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; EC 2.7.1.1/Hexokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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