Document Detail


Mitochondrial genetics and osteoarthritis .
MedLine Citation:
PMID:  23277056     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The genetic contribution is one of the most notable factors that play a main role in the risk of OA. Despite the genetics of this disease is complex and the finding of risk-related genes has been very challenging, evidence for genetic predisposition has been reported. Besides, in the last years recent evidences indicate that the mitochondrion is implicated in OA. In this context, the mtDNA haplogroups, defined as individual groups characterized by the presence of a particular set of single nucleotide polymorphisms (SNPs) in the mtDNA sequence, emerged as new genetic variants involved in this pathology. Moreover, it has been described that mtDNA damage not only accumulates in OA chondrocytes, but also that OA chondrocytes have limited mtDNA repair capacity. In this review we will focus on the influence of mitochondrial genetics and the mtDNA haplogroups in the prevalence, severity and progression of the OA disease, as well as their incidence on many OA-related features, such as serum levels of OA-related molecular markers, Nitric Oxide production or telomere length.
Authors:
Ignacio Rego-Perez; Mercedes Fernandez-Moreno; Angel Soto-Hermida; Carlos Fenandez-Lopez; Natividad Oreiro; Francisco J Blanco
Related Documents :
19573916 - Lack of association between the mdm2 promoter polymorphism snp309 and clinical outcome ...
22975156 - Egfr mutations and human papillomavirus in lung cancer.
16387716 - Aging and genome maintenance.
489996 - A search for association between igd concentrations and immunoglobulin allotypes in 936...
6794426 - Genetic studies among ramgarhias and ramdasias of punjab, north india.
22009356 - Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-8     Citation Subset:  IM    
Affiliation:
INIBIC-Complejo Hospitalario Universitario A Coruna, 15006-A Coruna, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reactive electrophilic metabolites of aromatic amine and amide carcinogens .
Next Document:  Biomimetic materials for controlling bone cell responses .