| Mitochondrial gene expression in elite cyclists: effects of high-intensity interval exercise. | |
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MedLine Citation:
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PMID: 20571821 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Little is known about the effect of training on genetic markers for mitochondrial biogenesis in elite athletes. We tested the hypothesis that low-volume sprint interval exercise (SIE) would be as effective as high-volume interval exercise (IE). Ten male cyclists competing on national elite level (W (max) 403 ± 13 W, VO(2peak) 68 ± 1 mL kg(-1) min(-1)) performed two interval exercise protocols: 7 × 30-s "all-out" bouts (SIE) and 3 × 20-min bouts at ~87% of VO(2peak) (IE). During IE, the work was eightfold larger (1,095 ± 43 vs. 135 ± 5 kJ) and the exercise duration 17 times longer (60 vs. 3.5 min) than during SIE. Muscle samples were taken before and 3 h after exercise. The mRNA of upstream markers of mitochondrial biogenesis [peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1α), PGC-1α-related coactivator (PRC) and peroxisome proliferator-activated receptor δ (PPARδ)] increased to the same extent after SIE and IE (6-, 1.5- and 1.5-fold increase, respectively). Of the downstream targets of PGC-1α, mitochondrial transcription factor A (Tfam) increased only after SIE and was significantly different from that after IE (P < 0.05), whereas others increased to the same extent (pyruvate dehydrogenase kinase, PDK4) or was unchanged (nuclear respiratory factor 2, NRF2). We conclude that upstream genetic markers of mitochondrial biogenesis increase in a similar way in elite athletes after one exercise session of SIE and IE. However, since the volume and duration of work was considerably lower during SIE and since Tfam, the downstream target of PGC-1α, increased only after SIE, we conclude that SIE might be a time-efficient training strategy for highly trained individuals. |
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Authors:
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Niklas Psilander; Psilander Niklas; Li Wang; Wang Li; Jens Westergren; Westergren Jens; Michail Tonkonogi; Tonkonogi Michail; Kent Sahlin; Sahlin Kent |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-23 |
Journal Detail:
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Title: European journal of applied physiology Volume: 110 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 597-606 Citation Subset: IM |
Affiliation:
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Astrand Laboratory, GIH, The Swedish School of Sport and Health Sciences, Box 5626, SE 114 86 Stockholm, Sweden. |
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| Comments/Corrections | |
Erratum In:
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Eur J Appl Physiol. 2010 Oct;110(3):607 Note: Niklas, Psilander [corrected to Psilander, Niklas]; Li, Wang [corrected to Wang, Li]; Jens, Westergren [corrected to Westergren, Jens]; Michail, Tonkonogi [corrected to Tonkonogi, Michail]; Kent, Sahlin [corrected to Sahlin, Kent] |
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