Document Detail


Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
MedLine Citation:
PMID:  16765926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The B vitamins are water-soluble vitamins required as coenzymes for enzymes essential for cell function. This review focuses on their essential role in maintaining mitochondrial function and on how mitochondria are compromised by a deficiency of any B vitamin. Thiamin (B1) is essential for the oxidative decarboxylation of the multienzyme branched-chain ketoacid dehydrogenase complexes of the citric acid cycle. Riboflavin (B2) is required for the flavoenzymes of the respiratory chain, while NADH is synthesized from niacin (B3) and is required to supply protons for oxidative phosphorylation. Pantothenic acid (B5) is required for coenzyme A formation and is also essential for alpha-ketoglutarate and pyruvate dehydrogenase complexes as well as fatty acid oxidation. Biotin (B7) is the coenzyme of decarboxylases required for gluconeogenesis and fatty acid oxidation. Pyridoxal (B6), folate and cobalamin (B12) properties are reviewed elsewhere in this issue. The experimental animal and clinical evidence that vitamin B therapy alleviates B deficiency symptoms and prevents mitochondrial toxicity is also reviewed. The effectiveness of B vitamins as antioxidants preventing oxidative stress toxicity is also reviewed.
Authors:
Flore Depeint; W Robert Bruce; Nandita Shangari; Rhea Mehta; Peter J O'Brien
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-05-01
Journal Detail:
Title:  Chemico-biological interactions     Volume:  163     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  94-112     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, University of Toronto, Canada; Department of Nutritional Sciences, University of Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotin / administration & dosage,  metabolism
Energy Metabolism / physiology
Humans
Mitochondria / drug effects,  metabolism*
Niacin / administration & dosage,  metabolism
Oxidative Stress / physiology
Pantothenic Acid / administration & dosage,  metabolism
Riboflavin / administration & dosage,  metabolism
Thiamine / administration & dosage,  metabolism
Vitamin B Complex / administration & dosage,  metabolism*
Vitamin B Deficiency / metabolism
Chemical
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 58-85-5/Biotin; 59-43-8/Thiamine; 59-67-6/Niacin; 79-83-4/Pantothenic Acid; 83-88-5/Riboflavin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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