Document Detail

Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition.
MedLine Citation:
PMID:  15820191     Owner:  NLM     Status:  MEDLINE    
Mitochondria have been suggested to be causally linked to age-related alterations through respiratory chain dysfunction and formation of reactive oxygen species, leading to damage of mitochondrial DNA. Impaired biosynthesis of respiratory chain and ATP synthase subunits encoded by mitochondrial genes would set up a vicious cycle contributing to the aging process. Mitochondria are also involved in the increased susceptibility to ischemic injury observed in aged hearts, a process where the mitochondrial permeability transition pore (PTP) may play a role. Here, we analyze (i) the possible mechanisms through which PTP opening might contribute to age-related myocardial alterations; (ii) the available evidence of an increased probability of PTP opening in mitochondria isolated from aged tissues; (iii) the current methodological limitations that complicate the elucidation of causal relationships between PTP opening, mitochondrial dysfunction, and myocardial aging.
Fabio Di Lisa; Paolo Bernardi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiovascular research     Volume:  66     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  222-32     Citation Subset:  IM    
Dipartimento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy.
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MeSH Terms
Aging / physiology*
Calcium / metabolism
Cell Death
Cell Respiration
DNA Damage
DNA, Mitochondrial
Electron Transport
Ion Channels / physiology*
Mitochondria, Heart / physiology*
Mitochondrial ADP, ATP Translocases / metabolism
Mitochondrial Membrane Transport Proteins
Myocardial Ischemia / metabolism,  pathology
Oxidative Stress
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/DNA, Mitochondrial; 0/Ion Channels; 0/Mitochondrial Membrane Transport Proteins; 0/Reactive Oxygen Species; 0/mitochondrial permeability transition pore; 7440-70-2/Calcium; 9068-80-8/Mitochondrial ADP, ATP Translocases

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