| Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition. | |
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MedLine Citation:
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PMID: 15820191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitochondria have been suggested to be causally linked to age-related alterations through respiratory chain dysfunction and formation of reactive oxygen species, leading to damage of mitochondrial DNA. Impaired biosynthesis of respiratory chain and ATP synthase subunits encoded by mitochondrial genes would set up a vicious cycle contributing to the aging process. Mitochondria are also involved in the increased susceptibility to ischemic injury observed in aged hearts, a process where the mitochondrial permeability transition pore (PTP) may play a role. Here, we analyze (i) the possible mechanisms through which PTP opening might contribute to age-related myocardial alterations; (ii) the available evidence of an increased probability of PTP opening in mitochondria isolated from aged tissues; (iii) the current methodological limitations that complicate the elucidation of causal relationships between PTP opening, mitochondrial dysfunction, and myocardial aging. |
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Authors:
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Fabio Di Lisa; Paolo Bernardi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cardiovascular research Volume: 66 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-11 Completed Date: 2005-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 222-32 Citation Subset: IM |
Affiliation:
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Dipartimento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy. dilisa@civ.bio.unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Calcium / metabolism Cell Death Cell Respiration DNA Damage DNA, Mitochondrial Electron Transport Humans Ion Channels / physiology* Mitochondria, Heart / physiology* Mitochondrial ADP, ATP Translocases / metabolism Mitochondrial Membrane Transport Proteins Myocardial Ischemia / metabolism, pathology Oxidative Stress Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial; 0/Ion Channels; 0/Mitochondrial Membrane Transport Proteins; 0/Reactive Oxygen Species; 0/mitochondrial permeability transition pore; 7440-70-2/Calcium; 9068-80-8/Mitochondrial ADP, ATP Translocases |
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