| Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir. | |
| | |
MedLine Citation:
|
PMID: 22293126 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity. METHODS: All patients had lipoatrophy on a tNRTI-containing regimen with HIV RNA<400 copies/ml. A randomized 48-week study switched patients from tNRTI to tenofovir (TDF) or added uridine (continuing tNRTI). End points were changes in limb fat (DEXA), subcutaneous abdominal fat mitochondrial DNA (mtDNA) and mitochondrial RNA (mtRNA), inflammation markers (soluble tumour necrosis factor receptors, high-sensitivity C reactive protein [hsCRP], interleukin-6 [IL-6], soluble vascular cell adhesion molecule 1), bone mineral density (BMD) of the hip and spine, HIV-1 RNA, CD4(+) T-cells and fasting metabolic parameters. RESULTS: Fifty patients were enrolled (n=24 TDF switch; n=26 uridine); median age 48 years; 54% white; 86% male; limb fat 4,494 g. Baseline characteristics were similar between groups. In the NucleomaxX(®) arm, mtRNA increased (all P<0.001), hsCRP and IL-6 increased (both P=0.02), whereas fat mtDNA decreased without changes in limb fat. In the TDF-switch arm, fat mtDNA and inflammation markers did not change; however, significant increases in mtRNAs (P<0.001), limb fat (409 g; IQR -59-1,155) and CD4(+) T-cell count (P=0.03), and decreases in total and hip BMD (median -3.3%; IQR -5.1-0; P=0.005) were observed. Between-group changes were significant for fat mtDNA, hsCRP, IL-6, limb fat and hip BMD. No correlation was found between changes in limb fat and those of fat mtRNA, inflammation markers or protease inhibitor duration. CONCLUSIONS: In HIV lipoatrophy, NucleomaxX(®) improved mtRNA, but worsened inflammation markers and fat mtDNA without changes in limb fat. Switching from a tNRTI to TDF for 48 weeks increased limb fat and fat mtRNA. Large decreases in total and hip BMD were seen after TDF switch.ClinicalTrials.gov identifier: NCT00119379. |
| | |
Authors:
|
Grace A McComsey; Maryann O'Riordan; Julia Choi; Daniel Libutti; David Rowe; Norma Storer; Danielle Harrill; Mariana Gerschenson |
Related Documents
:
|
11595676 - Binary taste mixture interactions in prop non-tasters, medium-tasters and super-tasters. 20536716 - Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-... 15120116 - Fructan metabolising enzymes in rhizophores of vernonia herbacea upon excision of aeria... 22504406 - Mitochondrial metabolism in aging: effect of dietary interventions. 8593086 - Factors that influence the level of contamination of human milk with poly-chlorinated o... 1153386 - Lack of response to supplemental tin, vanadium, chromium and nickel when added to a pur... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-13 |
Journal Detail:
|
Title: Antiviral therapy Volume: - ISSN: 2040-2058 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815705 Medline TA: Antivir Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA. mccomsey.grace@clevelandactu.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Trend of transfusion transmitted infections frequency in blood donors: provide a road map for its pr...
Next Document: Low energy spin dynamics in the spin ice Ho(2)Sn(2)O(7).