Document Detail

Mitochondrial function in physically active elders with sarcopenia.
MedLine Citation:
PMID:  19428449     Owner:  NLM     Status:  MEDLINE    
Physical activity is reported to protect against sarcopenia and preserve mitochondrial function. Healthy normal lean (NL: n=15) and sarcopenic (SS: n=9) participants were recruited based on body composition (DXA, Lunar DPX), age, and physical activity. Gastrocnemius mitochondrial function was assessed by (31)P MRS using steady-state exercise in a 4T Bruker Biospin. Total work (429.3+/-160.2J vs. 851.0+/-211.7J, p<0.001) and muscle volume (p=0.006) were lower in SS, although these variables were not correlated (NL r=-0.31, p=0.33, SS r=(0.03, p=0.93). In the SS resting ATP/ADP was lower (p=0.03) and ATP hydrolysis higher (p=0.02) at rest. Free energy ATP hydrolysis was greater at the end of exercise (p=0.02) and [ADP] relative to total work output was higher in SS (ANCOVA, p=0.005). [PCr] recovery kinetics were not different between the groups. Adjusting these parameters for differences in total work output and muscle volume did not explain these findings. These data suggest that aerobic metabolism in physically active older adults with sarcopenia is mildly impaired at rest and during modest levels of exercise where acidosis was avoided. Muscle energetics is coordinated at multiple cellular levels and further studies are needed to determine the loci/locus of energy instability in sarcopenia.
D L Waters; P G Mullins; C R Qualls; D S C Raj; C Gasparovic; R N Baumgartner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-02-06
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  130     ISSN:  1872-6216     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-06-29     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
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MeSH Terms
Energy Metabolism
Mitochondria, Muscle / metabolism,  physiology*
Muscle, Skeletal / metabolism,  pathology,  physiopathology*
Muscular Atrophy / metabolism,  physiopathology*
Organ Size
Grant Support
5MO1 RR00997/RR/NCRR NIH HHS; 5R21 AG21560/AG/NIA NIH HHS; M01 RR000997-31/RR/NCRR NIH HHS; R01 AG010149/AG/NIA NIH HHS; R01 AG010149-07/AG/NIA NIH HHS; R01 AG10149/AG/NIA NIH HHS; R21 AG021560-01A1/AG/NIA NIH HHS

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