| Mitochondrial function in physically active elders with sarcopenia. | |
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MedLine Citation:
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PMID: 19428449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical activity is reported to protect against sarcopenia and preserve mitochondrial function. Healthy normal lean (NL: n=15) and sarcopenic (SS: n=9) participants were recruited based on body composition (DXA, Lunar DPX), age, and physical activity. Gastrocnemius mitochondrial function was assessed by (31)P MRS using steady-state exercise in a 4T Bruker Biospin. Total work (429.3+/-160.2J vs. 851.0+/-211.7J, p<0.001) and muscle volume (p=0.006) were lower in SS, although these variables were not correlated (NL r=-0.31, p=0.33, SS r=(0.03, p=0.93). In the SS resting ATP/ADP was lower (p=0.03) and ATP hydrolysis higher (p=0.02) at rest. Free energy ATP hydrolysis was greater at the end of exercise (p=0.02) and [ADP] relative to total work output was higher in SS (ANCOVA, p=0.005). [PCr] recovery kinetics were not different between the groups. Adjusting these parameters for differences in total work output and muscle volume did not explain these findings. These data suggest that aerobic metabolism in physically active older adults with sarcopenia is mildly impaired at rest and during modest levels of exercise where acidosis was avoided. Muscle energetics is coordinated at multiple cellular levels and further studies are needed to determine the loci/locus of energy instability in sarcopenia. |
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Authors:
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D L Waters; P G Mullins; C R Qualls; D S C Raj; C Gasparovic; R N Baumgartner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-02-06 |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 130 ISSN: 1872-6216 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-06-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 315-9 Citation Subset: IM |
Affiliation:
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University of New Mexico, Health Sciences Center, School of Medicine, Albuquerque, New Mexico, United States. debra.waters@otago.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Energy Metabolism Exercise* Female Humans Male Mitochondria, Muscle / metabolism, physiology* Muscle, Skeletal / metabolism, pathology, physiopathology* Muscular Atrophy / metabolism, physiopathology* Organ Size |
| Grant Support | |
ID/Acronym/Agency:
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5MO1 RR00997/RR/NCRR NIH HHS; 5R21 AG21560/AG/NIA NIH HHS; M01 RR000997-31/RR/NCRR NIH HHS; R01 AG010149-07/AG/NIA NIH HHS; R01 AG10149/AG/NIA NIH HHS; R21 AG021560-01A1/AG/NIA NIH HHS |
| Comments/Corrections | |
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