Document Detail


Mitochondrial function in heart and kidney of spontaneously hypertensive rats: influence of captopril treatment.
MedLine Citation:
PMID:  20577032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effect of captopril treatment on capability of heart and kidney mitochondria to produce ATP was investigated in spontaneously hypertensive rats (SHR). Heart mitochondria from SHR responded to hypertension with tendency to compensate the elevated energy demands of cardiac cells by moderate increase in mitochondrial Mg2+-ATPase activity, membrane fluidity (MF) and in majority of functional parameters of the mitochondria (p>0.05). Significant increase exhibited only the oxygen consumption (QO2; p<0.01-0.001) and oxidative phosphorylation rate (OPR; p<0.003) with glutamate+malate (GLUT+MAL) as substrates. Lowering the blood pressure (p<0.02) captopril also eliminated the above compensatory response and impaired the oxidative ATP production by decreasing OPR (p<0.001). Kidney mitochondria of SHR experienced serious disarrangement in parameters of oxidative ATP production: increase in Mg2+-ATPase activity (p<0.05) but, also scattered QO2 values (p<0.03-0.01) leading to decrease in OPR and the ADP:O (p<0.05-0.01) values with both GLUT+MAL and succinate as substrates. Captopril treatment does not alleviated but even worsened the above alterations. Mg2+-ATPase became also decreased and the depression of ADP:O became aggravated (p<0.0001).
Authors:
Jana Mujkosová; Olga Ulicná; Iveta Waczulíková; Jana Vlkovicová; Ol'ga Vancová; Miroslav Ferko; Stefan Polák; Attila Ziegelhöffer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General physiology and biophysics     Volume:  29     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Affiliation:
Institute for Heart Research, Centre of Excellence for Cardiovascular Research, Slovak Academy of Sciences, 840 05 Bratislava, Slovakia. jana.mujkosova@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / biosynthesis*
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Animals
Antihypertensive Agents / pharmacology
Ca(2+) Mg(2+)-ATPase / metabolism
Captopril / pharmacology*
Energy Metabolism / drug effects
Hypertension / drug therapy*,  metabolism*
Kidney / drug effects*,  metabolism*
Mitochondria / drug effects,  metabolism
Mitochondria, Heart / drug effects*,  metabolism*
Rats
Rats, Inbred SHR
Rats, Wistar
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 56-65-5/Adenosine Triphosphate; 62571-86-2/Captopril; EC 3.6.1.-/Ca(2+) Mg(2+)-ATPase

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