Document Detail


Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes syndrome with hypothyroidism and focal segmental glomerulosclerosis in a paediatric patient.
MedLine Citation:
PMID:  17294289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Herein, we report on a paediatric patient with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) who was hospitalized for acute on chronic renal insufficiency, seizures and deterioration of the level of consciousness. She also had hypertension, hypothyroidism and nephrotic range proteinuria. Kidney biopsy revealed many sclerotic glomeruli and focal segmental glomerulosclerosis (FSGS). Glomerulopathy is rare in patients with MELAS, and FSGS has been reported only in a few patients. The histopathological features of the renal biopsy suggested that the aetiology of the FSGS may have been secondary to chronic renal injury rather than from a primary immunologic cause. Moreover, our case is unique in that, the coexistence of MELAS, hypothalamic hypothyroidism and FSGS has not been reported in the past. The purpose of this report is to increase the awareness of health-care professionals, especially in the fields of paediatrics, neurology, endocrinology and nephrology, regarding the manifestations and complications of MELAS.
Authors:
Keith K Lau; Samuel P Yang; Maha N Haddad; Lavjay Butani; Sudesh P Makker
Related Documents :
7910539 - Renal biopsy findings and clinicopathologic correlations in nephropathia epidemica.
3812469 - Chronic sclerosing glomerulopathy (heroin-associated nephropathy) in intravenous t's an...
11984599 - Replication and compartmentalization of hiv-1 in kidney epithelium of patients with hiv...
14701729 - Early glomerular filtration defect and severe renal disease in podocin-deficient mice.
23011309 - A new mutation in the human cytomegalovirus ul97 gene may confer ganciclovir resistance...
822859 - Triple-drug therapy of chronic glomerulopathies.
3294439 - Bacteriuria following extracorporeal shock wave lithotripsy of infection stones.
20335659 - Sirt1 activation protects the mouse renal medulla from oxidative injury.
272119 - Trichinosis in an immunosuppressed human host.
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-02-10
Journal Detail:
Title:  International urology and nephrology     Volume:  39     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-03     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  941-6     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of California, Davis, 2516 Stockton Blvd., Sacramento, CA 95817, USA. keith.lau@ucdmc.ucdavis.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / pathology
Comorbidity
Fatal Outcome
Female
Glomerulosclerosis, Focal Segmental / epidemiology*
Humans
Hypothyroidism / epidemiology*
Kidney / pathology
Kidney Glomerulus / pathology
Kidney Tubules / pathology
MELAS Syndrome / diagnosis,  epidemiology*
Magnetic Resonance Imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exploring dimensions of oral health-related quality of life using experts' opinions.
Next Document:  Importance of microbiological evaluation in management of infectious complications following percuta...