Document Detail

Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes syndrome with hypothyroidism and focal segmental glomerulosclerosis in a paediatric patient.
MedLine Citation:
PMID:  17294289     Owner:  NLM     Status:  MEDLINE    
Herein, we report on a paediatric patient with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) who was hospitalized for acute on chronic renal insufficiency, seizures and deterioration of the level of consciousness. She also had hypertension, hypothyroidism and nephrotic range proteinuria. Kidney biopsy revealed many sclerotic glomeruli and focal segmental glomerulosclerosis (FSGS). Glomerulopathy is rare in patients with MELAS, and FSGS has been reported only in a few patients. The histopathological features of the renal biopsy suggested that the aetiology of the FSGS may have been secondary to chronic renal injury rather than from a primary immunologic cause. Moreover, our case is unique in that, the coexistence of MELAS, hypothalamic hypothyroidism and FSGS has not been reported in the past. The purpose of this report is to increase the awareness of health-care professionals, especially in the fields of paediatrics, neurology, endocrinology and nephrology, regarding the manifestations and complications of MELAS.
Keith K Lau; Samuel P Yang; Maha N Haddad; Lavjay Butani; Sudesh P Makker
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-02-10
Journal Detail:
Title:  International urology and nephrology     Volume:  39     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-03     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  941-6     Citation Subset:  IM    
Department of Paediatrics, University of California, Davis, 2516 Stockton Blvd., Sacramento, CA 95817, USA.
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MeSH Terms
Brain / pathology
Fatal Outcome
Glomerulosclerosis, Focal Segmental / epidemiology*
Hypothyroidism / epidemiology*
Kidney / pathology
Kidney Glomerulus / pathology
Kidney Tubules / pathology
MELAS Syndrome / diagnosis,  epidemiology*
Magnetic Resonance Imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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